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Overview

Uniprot IDQ5RKG9
Protein NameEukaryotic translation initiation factor 4B
Gene NameEif4b
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
194 DRNRDSDKTDTDWRA
223 GDDSFGDKYRDRYES
333 RGPPQRPKLNLKPRS
343 LKPRSTPKEDDSSAS
365 ASIFGGAKPVDTAAR
486 PKENAWVKRSSNPPA
537 VDGVSTTKGQTGHSS
586 SEENRASKFSSASKY

Function

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F

Protein Sequence

10 MAASAKKKNK 20 KGKTISLTDF 30 LAEDGGTGGG 40 STYVPKPVSW 50 ADETDDLEGD 60 VSTTWHSNDD 70 DVYRAPPIDR 80 SILPTAPRAA 90 REPNIDRSRL 100 PKSPPYTAFL 110 GNLPYDVTED 120 SIKDFFRGLN 130 ISAVRLPREP 140 SNPDRLKGFG 150 YAEFEDLDSL 160 LSALSLNEES 170 LGNRRIRVDV 180 ADQAQDKDRD 190 DRSFGRDRNR 200 DSDKTDTDWR 210 ARPATDSFDD 220 YPPRRGDDSF 230 GDKYRDRYES 240 DRYRDGYRDG 250 YRDGPRRDMD 260 RYGGRDRYDD 270 RGSRDYDRGY 280 DSRIGSGRRA 290 FGSGYRRDDD 300 YRGGGDRYED 310 RYDRRDDRSW 320 SSRDDYSRDD 330 YRRDDRGPPQ 340 RPKLNLKPRS 350 TPKEDDSSAS 360 TSQSSRAASI 370 FGGAKPVDTA 380 AREREVEERL 390 QKEQEKLQRQ 400 LDEPKLDRRP 410 RERHPSWRSE 420 ETQERERSRT 430 GSESSQTGTS 440 ATSGRNTRRR 450 ESEKSLENET 460 LNKEEDCHSP 470 TSKPPKPDQP 480 LKVMPAPPPK 490 ENAWVKRSSN 500 PPARSQSSDT 510 EQPSPTSGGG 520 KVAPAQPSEE 530 GPSRKDETKV 540 DGVSTTKGQT 550 GHSSRGPGDG 560 GSRDHWKELD 570 RKDGKKDQDS 580 RSAPEPKKSE 590 ENRASKFSSA 600 SKYAALSVDG 610 EDEDEGDDCT E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0098794 postsynapse
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003743 translation initiation factor activity

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.