Search Results
Overview
| Uniprot ID | Q5RKH8 |
|---|---|
| Protein Name | RING-type E3 ubiquitin-protein ligase PPIL2 |
| Gene Name | Ppil2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 232 | MKPPEKKKVDQLNAA |
| 508 | STAIPTAKKRPSRGF |
Function
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Protein Sequence
10
MGKRQHQKDK
20
MYITCAEYTH
30
FYGGRKPDIT
40
QTSFRRLPFD
50
HCSLSLQPFV
60
YPVCTPEGVV
70
FDLLNIVPWL
80
KKYGTDPSTG
90
EKLDGKSLIK
100
LNFAKNSEGQ
110
YHCPVLYSVF
120
TDNTHIVAIR
130
TTGNVYTYEA
140
VEQLNIKAKN
150
LRDLLTDEPF
160
SRQDIITLQD
170
PTNLDKFNVS
180
SFFHVKNNMR
190
MIDPDEEKAK
200
QDPSYYLKNT
210
NAETRETLQE
220
LYKEFKGDEI
230
LAATMKPPEK
240
KKVDQLNAAH
250
YSTGKVSASF
260
TSTAMVPETT
270
HEAAVIDEDV
280
LRYQFVKKKG
290
YVRLHTNKGD
300
LNLELHCDLT
310
PKTCENFIKL
320
CKKQYYDGTI
330
FHRSIRNFVI
340
QGGDPTGTGT
350
GGESYWGKPF
360
KDEFRPNLSH
370
TGRGVLSMAN
380
SGPNTNKSQF
390
FITFRSCAYL
400
DKKHTIFGRV
410
VGGFDTLTAM
420
ENVESDPKTD
430
RPKEEVRICT
440
TTVFVDPYEE
450
ADAQIAQERK
460
KTQHQVDPEA
470
KAKTNQPQPG
480
NQGPQTYRQG
490
VGKYINPAAT
500
KRAAEEEPST
510
STAIPTAKKR
520
PSRGFGDFSS
W
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0008380 | RNA splicing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.