Search Results

Overview

Uniprot IDQ5RKI0
Protein NameWD repeat-containing protein 1
Gene NameWdr1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
106 QPFAGKIKDIAWTED
155 VINSVDIKQNRPYRL
182 EGPPFKFKFTIGDHS
21 QVERGVSKILGGDPK
311 LDKNNPSKPLRVIKG
321 RVIKGHSKSIQCLTV
480 SILGATLKDEGKLLE
569 SDPETKVKIQDAHRL
7 *MPYEIKKVFASLPQ
90 RIWDTTQKEHILKYE

Function

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity)

Protein Sequence

10 MPYEIKKVFA 20 SLPQVERGVS 30 KILGGDPKGD 40 NFLYTNGKCV 50 ILRNIDNPAV 60 ADIYTEHAHQ 70 VVVAKYAPSG 80 FYIASGDISG 90 KLRIWDTTQK 100 EHILKYEYQP 110 FAGKIKDIAW 120 TEDSKRIAVV 130 GEGREKFGAV 140 FLWDTGSSVG 150 EITGHNKVIN 160 SVDIKQNRPY 170 RLATGSDDNC 180 AAFFEGPPFK 190 FKFTIGDHSR 200 FVNCVRFSPD 210 GNRFATASAD 220 GQIFIYDGKT 230 GEKVCALGGS 240 KAHDGGIYAI 250 SWSPDSTHLL 260 SASGDKTSKI 270 WDVNVNSVVS 280 TFPMGSNVLD 290 QQLGCLWQKD 300 HLLSISLSGY 310 INYLDKNNPS 320 KPLRVIKGHS 330 KSIQCLTVHK 340 NGGKSYIYSG 350 SHDGHINYWD 360 SETGENDSFS 370 GKGHTNQVSR 380 MTVDESGQLV 390 SCSMDDTVRY 400 TNLTLRDYSG 410 QGVVKLDVQP 420 KCVAVGPGGY 430 TVVVCIGQIV 440 LLKDQKKCFS 450 IDNPGYEPEV 460 VAVHPGGDTV 470 AVGGSDGNVR 480 VYSILGATLK 490 DEGKLLEAKG 500 PVTDLAYSHD 510 GAFLAVCDAS 520 KVVTVFSVAD 530 GYSENNVFYG 540 HHAKIVCLAW 550 SPDNEHFASG 560 GMDMMVYVWT 570 LSDPETKVKI 580 QDAHRLHHVS 590 SLAWLDEHTL 600 VTTSHDASVK EWTITY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0002102 podosome
Cellular Component GO:0045202 synapse
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0030042 actin filament depolymerization
Biological Process GO:0030043 actin filament fragmentation
Biological Process GO:0043297 apical junction assembly
Biological Process GO:0030865 cortical cytoskeleton organization
Biological Process GO:0042247 establishment of planar polarity of follicular epithelium
Biological Process GO:0040011 locomotion
Biological Process GO:0045199 maintenance of epithelial cell apical/basal polarity
Biological Process GO:0002446 neutrophil mediated immunity
Biological Process GO:1990266 neutrophil migration
Biological Process GO:0030220 platelet formation
Biological Process GO:0030836 positive regulation of actin filament depolymerization
Biological Process GO:0030834 regulation of actin filament depolymerization
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0048713 regulation of oligodendrocyte differentiation
Biological Process GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
Biological Process GO:0045214 sarcomere organization

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.