Search Results
Overview
| Uniprot ID | Q5RKI1 |
|---|---|
| Protein Name | Eukaryotic initiation factor 4A-II |
| Gene Name | Eif4a2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | NVRNEMQKLQAEAPH |
Function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity)
Protein Sequence
10
MSGGSADYNR
20
EHGGPEGMDP
30
DGVIESNWNE
40
IVDNFDDMNL
50
KESLLRGIYA
60
YGFEKPSAIQ
70
QRAIIPCIKG
80
YDVIAQAQSG
90
TGKTATFAIS
100
ILQQLEIEFK
110
ETQALVLAPT
120
RELAQQIQKV
130
ILALGDYMGA
140
TCHACIGGTN
150
VRNEMQKLQA
160
EAPHIVVGTP
170
GRVFDMLNRR
180
YLSPKWIKMF
190
VLDEADEMLS
200
RGFKDQIYEI
210
FQKLNTSIQV
220
VLLSATMPTD
230
VLEVTKKFMR
240
DPIRILVKKE
250
ELTLEGIKQF
260
YINVEREEWK
270
LDTLCDLYET
280
LTITQAVIFL
290
NTRRKVDWLT
300
EKMHARDFTV
310
SALHGDMDQK
320
ERDVIMREFR
330
SGSSRVLITT
340
DLLARGIDVQ
350
QVSLVINYDL
360
PTNRENYIHR
370
IGRGGRFGRK
380
GVAINFVTEE
390
DKRILRDIET
400
FYNTTVEEMP
MNVADLI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0002183 | cytoplasmic translational initiation |
| Biological Process | GO:1900260 | negative regulation of RNA-dependent RNA polymerase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.