Search Results
Overview
| Uniprot ID | Q5S1U1 |
|---|---|
| Protein Name | Heat shock protein beta-1 |
| Gene Name | HSPB1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | APEELTVKTKDGVVE |
| 116 | EELTVKTKDGVVEIT |
| 125 | GVVEITGKHEERQDE |
| 200 | LGGTEAGKSEKPGTK |
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins
Protein Sequence
10
MTERRVPFSL
20
LRSPSWDPFR
30
DWYPAHSRLF
40
DQAFGLPRLP
50
EEWSQWLSHS
60
GWPGYVRPLP
70
PPAIEGPAAV
80
AAPAYSRLLS
90
RQLSSGVSEI
100
QQTADRWRVS
110
LDVNHFAPEE
120
LTVKTKDGVV
130
EITGKHEERQ
140
DEHGFISRCF
150
TRKYTLPPGV
160
DPTQVSSSLS
170
PEGTLSVEAP
180
LPKPATQSAE
190
ITIPVTFEAR
200
AQLGGTEAGK
SEKPGTK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0099641 | anterograde axonal protein transport |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0042026 | protein refolding |
| Biological Process | GO:0001932 | regulation of protein phosphorylation |
| Biological Process | GO:0009408 | response to heat |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.