Search Results

Overview

Uniprot ID	Q5SSJ5
Protein Name	Heterochromatin protein 1-binding protein 3
Gene Name	HP1BP3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
131	EKEKKVKKTIPSWAT
283	ASYSLIRKYVSQYYP
365	TCSTTALKKYVLENH
482	RGSKPAPKVSAAQRG
536	TSARKEVKLPGKGKS

Function

Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860)

Protein Sequence

10 MATDTSQGEL 20 VHPKALPLIV 30 GAQLIHADKL 40 GEKVEDSTMP 50 IRRTVNSTRE 60 TPPKSKLAEG 70 EEEKPEPDIS 80 SEESVSTVEE 90 QENETPPATS 100 SEAEQPKGEP 110 ENEEKEENKS 120 SEETKKDEKD 130 QSKEKEKKVK 140 KTIPSWATLS 150 ASQLARAQKQ 160 TPMASSPRPK 170 MDAILTEAIK 180 ACFQKSGASV 190 VAIRKYIIHK 200 YPSLELERRG 210 YLLKQALKRE 220 LNRGVIKQVK 230 GKGASGSFVV 240 VQKSRKTPQK 250 SRNRKNRSSA 260 VDPEPQVKLE 270 DVLPLAFTRL 280 CEPKEASYSL 290 IRKYVSQYYP 300 KLRVDIRPQL 310 LKNALQRAVE 320 RGQLEQITGK 330 GASGTFQLKK 340 SGEKPLLGGS 350 LMEYAILSAI 360 AAMNEPKTCS 370 TTALKKYVLE 380 NHPGTNSNYQ 390 MHLLKKTLQK 400 CEKNGWMEQI 410 SGKGFSGTFQ 420 LCFPYYPSPG 430 VLFPKKEPDD 440 SRDEDEDEDE 450 SSEEDSEDEE 460 PPPKRRLQKK 470 TPAKSPGKAA 480 SVKQRGSKPA 490 PKVSAAQRGK 500 ARPLPKKAPP 510 KAKTPAKKTR 520 PSSTVIKKPS 530 GGSSKKPATS 540 ARKEVKLPGK 550 GKSTMKKSFR VKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0000786	nucleosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0031491	nucleosome binding
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0070828	heterochromatin organization
Biological Process	GO:0006334	nucleosome assembly
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0097298	regulation of nucleus size

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.