Search Results

Overview

Uniprot IDQ5T0N5
Protein NameFormin-binding protein 1-like
Gene NameFNBP1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
131 QYLDMCWKQMDNSKK
303 DGTISASKQESGKMD
321 TVGKAKGKLWLFGKK

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens

Protein Sequence

10 MSWGTELWDQ 20 FDSLDKHTQW 30 GIDFLERYAK 40 FVKERIEIEQ 50 NYAKQLRNLV 60 KKYCPKRSSK 70 DEEPRFTSCV 80 AFFNILNELN 90 DYAGQREVVA 100 EEMAHRVYGE 110 LMRYAHDLKT 120 ERKMHLQEGR 130 KAQQYLDMCW 140 KQMDNSKKKF 150 ERECREAEKA 160 QQSYERLDND 170 TNATKADVEK 180 AKQQLNLRTH 190 MADENKNEYA 200 AQLQNFNGEQ 210 HKHFYVVIPQ 220 IYKQLQEMDE 230 RRTIKLSECY 240 RGFADSERKV 250 IPIISKCLEG 260 MILAAKSVDE 270 RRDSQMVVDS 280 FKSGFEPPGD 290 FPFEDYSQHI 300 YRTISDGTIS 310 ASKQESGKMD 320 AKTTVGKAKG 330 KLWLFGKKPK 340 PQSPPLTPTS 350 LFTSSTPNGS 360 QFLTFSIEPV 370 HYCMNEIKTG 380 KPRIPSFRSL 390 KRGWSVKMGP 400 ALEDFSHLPP 410 EQRRKKLQQR 420 IDELNRELQK 430 ESDQKDALNK 440 MKDVYEKNPQ 450 MGDPGSLQPK 460 LAETMNNIDR 470 LRMEIHKNEA 480 WLSEVEGKTG 490 GRGDRRHSSD 500 INHLVTQGRE 510 SPEGSYTDDA 520 NQEVRGPPQQ 530 HGHHNEFDDE 540 FEDDDPLPAI 550 GHCKAIYPFD 560 GHNEGTLAMK 570 EGEVLYIIEE 580 DKGDGWTRAR 590 RQNGEEGYVP 600 TSYIDVTLEK NSKGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0008289 lipid binding
Biological Process GO:0006914 autophagy
Biological Process GO:0060271 cilium assembly
Biological Process GO:0072583 clathrin-dependent endocytosis
Biological Process GO:0010324 membrane invagination
Biological Process GO:0097320 plasma membrane tubulation
Biological Process GO:0051491 positive regulation of filopodium assembly
Biological Process GO:0007165 signal transduction
Biological Process GO:0006900 vesicle budding from membrane
Biological Process GO:0016050 vesicle organization
Biological Process GO:0030050 vesicle transport along actin filament

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.