Search Results
Overview
| Uniprot ID | Q5T160 |
|---|---|
| Protein Name | Probable arginine--tRNA ligase, mitochondrial |
| Gene Name | RARS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | FSSPNVAKKFHVGHL |
Function
Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg)
Protein Sequence
10
MACGFRRAIA
20
CQLSRVLNLP
30
PENLITSISA
40
VPISQKEEVA
50
DFQLSVDSLL
60
EKDNDHSRPD
70
IQVQAKRLAE
80
KLRCDTVVSE
90
ISTGQRTVNF
100
KINRELLTKT
110
VLQQVIEDGS
120
KYGLKSELFS
130
GLPQKKIVVE
140
FSSPNVAKKF
150
HVGHLRSTII
160
GNFIANLKEA
170
LGHQVIRINY
180
LGDWGMQFGL
190
LGTGFQLFGY
200
EEKLQSNPLQ
210
HLFEVYVQVN
220
KEAADDKSVA
230
KAAQEFFQRL
240
ELGDVQALSL
250
WQKFRDLSIE
260
EYIRVYKRLG
270
VYFDEYSGES
280
FYREKSQEVL
290
KLLESKGLLL
300
KTIKGTAVVD
310
LSGNGDPSSI
320
CTVMRSDGTS
330
LYATRDLAAA
340
IDRMDKYNFD
350
TMIYVTDKGQ
360
KKHFQQVFQM
370
LKIMGYDWAE
380
RCQHVPFGVV
390
QGMKTRRGDV
400
TFLEDVLNEI
410
QLRMLQNMAS
420
IKTTKELKNP
430
QETAERVGLA
440
ALIIQDFKGL
450
LLSDYKFSWD
460
RVFQSRGDTG
470
VFLQYTHARL
480
HSLEETFGCG
490
YLNDFNTACL
500
QEPQSVSILQ
510
HLLRFDEVLY
520
KSSQDFQPRH
530
IVSYLLTLSH
540
LAAVAHKTLQ
550
IKDSPPEVAG
560
ARLHLFKAVR
570
SVLANGMKLL
GITPVCRM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004814 | arginine-tRNA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006420 | arginyl-tRNA aminoacylation |
| Biological Process | GO:0032543 | mitochondrial translation |
| Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.