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Overview

Uniprot ID	Q5T1M5
Protein Name	FK506-binding protein 15
Gene Name	FKBP15
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
49	TAPKQPKKGQGTAAT

Function

May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement

Protein Sequence

10 MFGAGDEDDT 20 DFLSPSGGAR 30 LASLFGLDQA 40 AAGHGNEFFQ 50 YTAPKQPKKG 60 QGTAATGNQA 70 TPKTAPATMS 80 TPTILVATAV 90 HAYRYTNGQY 100 VKQGKFGAAV 110 LGNHTAREYR 120 ILLYISQQQP 130 VTVARIHVNF 140 ELMVRPNNYS 150 TFYDDQRQNW 160 SIMFESEKAA 170 VEFNKQVCIA 180 KCNSTSSLDA 190 VLSQDLIVAD 200 GPAVEVGDSL 210 EVAYTGWLFQ 220 NHVLGQVFDS 230 TANKDKLLRL 240 KLGSGKVIKG 250 WEDGMLGMKK 260 GGKRLLIVPP 270 ACAVGSEGVI 280 GWTQATDSIL 290 VFEVEVRRVK 300 FARDSGSDGH 310 SVSSRDSAAP 320 SPIPGADNLS 330 ADPVVSPPTS 340 IPFKSGEPAL 350 RTKSNSLSEQ 360 LAINTSPDAV 370 KAKLISRMAK 380 MGQPMLPILP 390 PQLDSNDSEI 400 EDVNTLQGGG 410 QPVVTPSVQP 420 SLHPAHPALP 430 QMTSQAPQPS 440 VTGLQAPSAA 450 LMQVSSLDSH 460 SAVSGNAQSF 470 QPYAGMQAYA 480 YPQASAVTSQ 490 LQPVRPLYPA 500 PLSQPPHFQG 510 SGDMASFLMT 520 EARQHNTEIR 530 MAVSKVADKM 540 DHLMTKVEEL 550 QKHSAGNSML 560 IPSMSVTMET 570 SMIMSNIQRI 580 IQENERLKQE 590 ILEKSNRIEE 600 QNDKISELIE 610 RNQRYVEQSN 620 LMMEKRNNSL 630 QTATENTQAR 640 VLHAEQEKAK 650 VTEELAAATA 660 QVSHLQLKMT 670 AHQKKETELQ 680 MQLTESLKET 690 DLLRGQLTKV 700 QAKLSELQET 710 SEQAQSKFKS 720 EKQNRKQLEL 730 KVTSLEEELT 740 DLRVEKESLE 750 KNLSERKKKS 760 AQERSQAEEE 770 IDEIRKSYQE 780 ELDKLRQLLK 790 KTRVSTDQAA 800 AEQLSLVQAE 810 LQTQWEAKCE 820 HLLASAKDEH 830 LQQYQEVCAQ 840 RDAYQQKLVQ 850 LQEKCLALQA 860 QITALTKQNE 870 QHIKELEKNK 880 SQMSGVEAAA 890 SDPSEKVKKI 900 MNQVFQSLRR 910 EFELEESYNG 920 RTILGTIMNT 930 IKMVTLQLLN 940 QQEQEKEESS 950 SEEEEEKAEE 960 RPRRPSQEQS 970 ASASSGQPQA 980 PLNRERPESP 990 MVPSEQVVEE 1000 AVPLPPQALT 1010 TSQDGHRRKG 1020 DSEAEALSEI 1030 KDGSLPPELS 1040 CIPSHRVLGP 1050 PTSIPPEPLG 1060 PVSMDSECEE 1070 SLAASPMAAK 1080 PDNPSGKVCV 1090 REVAPDGPLQ 1100 ESSTRLSLTS 1110 DPEEGDPLAL 1120 GPESPGEPQP 1130 PQLKKDDVTS 1140 STGPHKELSS 1150 TEAGSTVAGA 1160 ALRPSHHSQR 1170 SSLSGDEEDE 1180 LFKGATLKAL 1190 RPKAQPEEED 1200 EDEVSMKGRP 1210 PPTPLFGDDD DDDDIDWLG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0016020	membrane
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
Biological Process	GO:0006897	endocytosis

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.