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Overview

Uniprot ID	Q5T200
Protein Name	Zinc finger CCCH domain-containing protein 13
Gene Name	ZC3H13
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
102	DVDTEPQKRNTEESS
1167	CHRTRVEKVETPHVT
1239	SRDREKTKSLEITGE
1388	SSQIESVKRCEAKLE
1393	SVKRCEAKLEGEHER
205	SPEVVRSKLSPSPSL
236	SASKKDRKTSAVSSP
47	TQCRNWLKTGNCLYG
7	*MSKIRRKVTVENTK
970	QKKPIKKKKEDDVGI

Function

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity)

Protein Sequence

10 MSKIRRKVTV 20 ENTKTISDST 30 SRRPSVFERL 40 GPSTGSTAET 50 QCRNWLKTGN 60 CLYGNTCRFV 70 HGPSPRGKGY 80 SSNYRRSPER 90 PTGDLRERMK 100 NKRQDVDTEP 110 QKRNTEESSS 120 PVRKESSRGR 130 HREKEDIKIT 140 KERTPESEEE 150 NVEWETNRDD 160 SDNGDINYDY 170 VHELSLEMKR 180 QKIQRELMKL 190 EQENMEKREE 200 IIIKKEVSPE 210 VVRSKLSPSP 220 SLRKSSKSPK 230 RKSSPKSSSA 240 SKKDRKTSAV 250 SSPLLDQQRN 260 SKTNQSKKKG 270 PRTPSPPPPI 280 PEDIALGKKY 290 KEKYKVKDRI 300 EEKTRDGKDR 310 GRDFERQREK 320 RDKPRSTSPA 330 GQHHSPISSR 340 HHSSSSQSGS 350 SIQRHSPSPR 360 RKRTPSPSYQ 370 RTLTPPLRRS 380 ASPYPSHSLS 390 SPQRKQSPPR 400 HRSPMREKGR 410 HDHERTSQSH 420 DRRHERREDT 430 RGKRDREKDS 440 REEREYEQDQ 450 SSSRDHRDDR 460 EPRDGRDRRD 470 ARDTRDRREL 480 RDSRDMRDSR 490 EMRDYSRDTK 500 ESRDPRDSRS 510 TRDAHDYRDR 520 EGRDTHRKED 530 TYPEESRSYG 540 RNHLREESSR 550 TEIRNESRNE 560 SRSEIRNDRM 570 GRSRGRVPEL 580 PEKGSRGSRG 590 SQIDSHSSNS 600 NYHDSWETRS 610 SYPERDRYPE 620 RDNRDQARDS 630 SFERRHGERD 640 RRDNRERDQR 650 PSSPIRHQGR 660 NDELERDERR 670 EERRVDRVDD 680 RRDERARERD 690 RERERDRERE 700 RERERERDRE 710 REKERELERE 720 RARERERERE 730 KERDRERDRD 740 RDHDRERERE 750 RERDREKERE 760 REREERERER 770 ERERERERER 780 ERERERARER 790 DKERERQRDW 800 EDKDKGRDDR 810 REKREEIRED 820 RNPRDGHDER 830 KSKKRYRNEG 840 SPSPRQSPKR 850 RREHSPDSDA 860 YNSGDDKNEK 870 HRLLSQVVRP 880 QESRSLSPSH 890 LTEDRQGRWK 900 EEDRKPERKE 910 SSRRYEEQEL 920 KEKVSSVDKQ 930 REQTEILESS 940 RMRAQDIIGH 950 HQSEDRETSD 960 RAHDENKKKA 970 KIQKKPIKKK 980 KEDDVGIERG 990 NIETTSEDGQ 1000 VFSPKKGQKK 1010 KSIEKKRKKS 1020 KGDSDISDEE 1030 AAQQSKKKRG 1040 PRTPPITTKE 1050 ELVEMCNGKN 1060 GILEDSQKKE 1070 DTAFSDWSDE 1080 DVPDRTEVTE 1090 AEHTATATTP 1100 GSTPSPLSSL 1110 LPPPPPVATA 1120 TATTVPATLA 1130 ATTAAAATSF 1140 STSAITISTS 1150 ATPTNTTNNT 1160 FANEDSHRKC 1170 HRTRVEKVET 1180 PHVTIEDAQH 1190 RKPMDQKRSS 1200 SLGSNRSNRS 1210 HTSGRLRSPS 1220 NDSAHRSGDD 1230 QSGRKRVLHS 1240 GSRDREKTKS 1250 LEITGERKSR 1260 IDQLKRGEPS 1270 RSTSSDRQDS 1280 RSHSSRRSSP 1290 ESDRQVHSRS 1300 GSFDSRDRLQ 1310 ERDRYEHDRE 1320 RERERRDTRQ 1330 REWDRDADKD 1340 WPRNRDRDRL 1350 RERERERERD 1360 KRRDLDRERE 1370 RLISDSVERD 1380 RDRDRDRTFE 1390 SSQIESVKRC 1400 EAKLEGEHER 1410 DLESTSRDSL 1420 ALDKERMDKD 1430 LGSVQGFEET 1440 NKSERTESLE 1450 GDDESKLDDA 1460 HSLGSGAGEG 1470 YEPISDDELD 1480 EILAGDAEKR 1490 EDQQDEEKMP 1500 DPLDVIDVDW 1510 SGLMPKHPKE 1520 PREPGAALLK 1530 FTPGAVMLRV 1540 GISKKLAGSE 1550 LFAKVKETCQ 1560 RLLEKPKDAD 1570 NLFEHELGAL 1580 NMAALLRKEE 1590 RASLLSNLGP 1600 CCKALCFRRD 1610 SAIRKQLVKN 1620 EKGTIKQAYT 1630 SAPMVDNELL 1640 RLSLRLFKRK 1650 TTCHAPGHEK 1660 TEDNKLSQSS IQQELCVS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:2000036	regulation of stem cell population maintenance
Biological Process	GO:0008380	RNA splicing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.