Overview
| Uniprot ID | Q5T2W1 |
|---|
| Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 |
|---|
| Gene Name | PDZK1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 224 |
DKRHVEQKIQFKRET |
| 235 |
KRETASLKLLPHQPR |
| 264 |
LRAGSEQKGQIIKDI |
| 269 |
EQKGQIIKDIDSGSP |
| 28 |
GFFLRIEKDTEGHLV |
| 448 |
DRIQSSGKNVTLLVC |
| 458 |
TLLVCGKKAYDYFQA |
| 466 |
AYDYFQAKKIPIVSS |
| 500 |
NHDSHMAKERAHSTA |
| 77 |
QVVDLVRKSGNSVTL |
Function
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity)
Protein Sequence
10
MTSTFNPREC
20
KLSKQEGQNY
30
GFFLRIEKDT
40
EGHLVRVVEK
50
CSPAEKAGLQ
60
DGDRVLRING
70
VFVDKEEHMQ
80
VVDLVRKSGN
90
SVTLLVLDGD
100
SYEKAVKTRV
110
DLKELGQSQK
120
EQGLSDNILS
130
PVMNGGVQTW
140
TQPRLCYLVK
150
EGGSYGFSLK
160
TVQGKKGVYM
170
TDITPQGVAM
180
RAGVLADDHL
190
IEVNGENVED
200
ASHEEVVEKV
210
KKSGSRVMFL
220
LVDKETDKRH
230
VEQKIQFKRE
240
TASLKLLPHQ
250
PRIVEMKKGS
260
NGYGFYLRAG
270
SEQKGQIIKD
280
IDSGSPAEEA
290
GLKNNDLVVA
300
VNGESVETLD
310
HDSVVEMIRK
320
GGDQTSLLVV
330
DKETDNMYRL
340
AHFSPFLYYQ
350
SQELPNGSVK
360
EAPAPTPTSL
370
EVSSPPDTTE
380
EVDHKPKLCR
390
LAKGENGYGF
400
HLNAIRGLPG
410
SFIKEVQKGG
420
PADLAGLEDE
430
DVIIEVNGVN
440
VLDEPYEKVV
450
DRIQSSGKNV
460
TLLVCGKKAY
470
DYFQAKKIPI
480
VSSLADPLDT
490
PPDSKEGIVV
500
ESNHDSHMAK
510
ERAHSTASHS
SSNSEDTEM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0005903 |
brush border |
| Cellular Component |
GO:0031526 |
brush border membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031528 |
microvillus membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0030165 |
PDZ domain binding |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0043495 |
protein-membrane adaptor activity |
| Molecular Function |
GO:0005124 |
scavenger receptor binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:0141109 |
transporter activator activity |
| Biological Process |
GO:1902603 |
carnitine transmembrane transport |
| Biological Process |
GO:1905477 |
positive regulation of protein localization to membrane |
| Biological Process |
GO:0090314 |
positive regulation of protein targeting to membrane |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0044070 |
regulation of monoatomic anion transport |
| Biological Process |
GO:1990961 |
xenobiotic detoxification by transmembrane export across the plasma membrane |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.