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Overview

Uniprot IDQ5T3J3
Protein NameLigand-dependent nuclear receptor-interacting factor 1
Gene NameLRIF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
316 SSNNVASKILKTFVD

Function

Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133)

Protein Sequence

10 MSNNLRRVFL 20 KPAEENSGNA 30 SRCVSGCMYQ 40 VVQTIGSDGK 50 NLLQLLPIPK 60 SSGNLIPLVQ 70 SSVMSDALKG 80 NTGKPVQVTF 90 QTQISSSSTS 100 ASVQLPIFQP 110 ASSSNYFLTR 120 TVDTSEKGRV 130 TSVGTGNFSS 140 SVSKVQSHGV 150 KIDGLTMQTF 160 AVPPSTQKDS 170 SFIVVNTQSL 180 PVTVKSPVLP 190 SGHHLQIPAH 200 AEVKSVPASS 210 LPPSVQQKIL 220 ATATTSTSGM 230 VEASQMPTVI 240 YVSPVNTVKN 250 VVTKNFQNIY 260 PKPVTEIAKP 270 VILNTTQIPK 280 NVATETQLKG 290 GQHSQAAPVK 300 WIFQDNLQPF 310 TPSLVPVKSS 320 NNVASKILKT 330 FVDRKNLGDN 340 TINMPPLSTI 350 DPSGTRSKNM 360 PIKDNALVMF 370 NGKVYLLAKK 380 GTDVLPSQID 390 QQNSVSPDTP 400 VRKDTLQTVS 410 SSPVTEISRE 420 VVNIVLAKSK 430 SSQMETKSLS 440 NTQLASMANL 450 RAEKNKVEKP 460 SPSTTNPHMN 470 QSSNYLKQSK 480 TLFTNPIFPV 490 GFSTGHNAPR 500 KVTAVIYARK 510 GSVLQSIEKI 520 SSSVDATTVT 530 SQQCVFRDQE 540 PKIHNEMAST 550 SDKGAQGRND 560 KKDSQGRSNK 570 ALHLKSDAEF 580 KKIFGLTKDL 590 RVCLTRIPDH 600 LTSGEGFDSF 610 SSLVKSGTYK 620 ETEFMVKEGE 630 RKQQNFDKKR 640 KAKTNKKMDH 650 IKKRKTENAY 660 NAIINGEANV 670 TGSQLLSSIL 680 PTSDVSQHNI 690 LTSHSKTRQE 700 KRTEMEYYTH 710 EKQEKGTLNS 720 NAAYEQSHFF 730 NKNYTEDIFP 740 VTPPELEETI 750 RDEKIRRLKQ 760 VLREKEAALE EMRKKMHQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001740 Barr body
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0042974 nuclear retinoic acid receptor binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0009048 dosage compensation by inactivation of X chromosome
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.