Search Results
Overview
| Uniprot ID | Q5T440 |
|---|---|
| Protein Name | Iron-sulfur cluster assembly factor IBA57, mitochondrial |
| Gene Name | IBA57 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | ALYRIRRKVTVEPHP |
Function
Mitochondrial protein involved in the maturation of mitochondrial [4Fe-4S]-proteins in the late stage of the iron-sulfur cluster assembly pathway (PubMed:22323289, PubMed:23462291). Operates in cooperation with ISCA2 in the maturation of [4Fe-4S] proteins (PubMed:30269484)
Protein Sequence
10
MATAALLRGA
20
TPGRGGPVWR
30
WRLRAAPRCR
40
LAHSSCSPGG
50
DPTAGAAWAC
60
FRLDGRTLLR
70
VRGPDAAPFL
80
LGLLTNELPL
90
PSPAAAGAPP
100
AARAGYAHFL
110
NVQGRTLYDV
120
ILYGLQEHSE
130
VSGFLLECDS
140
SVQGALQKHL
150
ALYRIRRKVT
160
VEPHPELRVW
170
AVLPSSPEAC
180
GAASLQERAG
190
AAAILIRDPR
200
TARMGWRLLT
210
QDEGPALVPG
220
GRLGDLWDYH
230
QHRYLQGVPE
240
GVRDLPPGVA
250
LPLESNLAFM
260
NGVSFTKGCY
270
IGQELTARTH
280
HMGVIRKRLF
290
PVRFLDPLPT
300
SGITPGATVL
310
TASGQTVGKF
320
RAGQGNVGLA
330
LLWSEKIKGP
340
LHIRASEGAQ
350
VALAASVPDW
WPTVSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006783 | heme biosynthetic process |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.