Overview
| Uniprot ID | Q5T4U5 |
|---|
| Protein Name | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | ACADM |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 428 |
EKLMRDAKIYQIYEG |
Function
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16
Protein Sequence
10
MAAGFGRCCR
20
VLRSISRFHW
30
RSQHTKANRQ
40
REPGLGFSFE
50
FTEQQKEFQA
60
TARKFAREEI
70
IPVAAEYDKT
80
GEYPVPLIRR
90
AWELGLMNTH
100
IPENCDYSVC
110
PLLEACTLYL
120
DAFFLLLTGS
130
NLNLHLNLGG
140
LGLGTFDACL
150
ISEELAYGCT
160
GVQTAIEGNS
170
LGQMPIIIAG
180
NDQQKKKYLG
190
RMTEEPLMCA
200
YCVTEPGAGS
210
DVAGIKTKAE
220
KKGDEYIING
230
QKMWITNGGK
240
ANWYFLLARS
250
DPDPKAPANK
260
AFTGFIVEAD
270
TPGIQIGRKE
280
LNMGQRCSDT
290
RGIVFEDVKV
300
PKENVLIGDG
310
AGFKVAMGAF
320
DKTRPVVAAG
330
AVGLAQRALD
340
EATKYALERK
350
TFGKLLVEHQ
360
AISFMLAEMA
370
MKVELARMSY
380
QRAAWEVDSG
390
RRNTYYASIA
400
KAFAGDIANQ
410
LATDAVQILG
420
GNGFNTEYPV
430
EKLMRDAKIY
440
QIYEGTSQIQ
450
RLIVAREHID
KYKN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0070991 |
medium-chain fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0006635 |
fatty acid beta-oxidation |
Reference
PMID: N/A