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Overview

Uniprot IDQ5T5X7
Protein NameBEN domain-containing protein 3
Gene NameBEND3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 DATTPSYKKPLYGIS
129 ATTPSYKKPLYGISH
142 SHKIMEKKNPPSGDL
158 NVYELFEKANASNSP
659 RSYQQQRKVHVPGPE
73 LDSVPGVKRRRLIPE

Function

Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671)

Protein Sequence

10 MNSTEFTEDV 20 EEVLKSITVK 30 VETEAEDAAL 40 DCSVNSRTSE 50 KHSVDSVLTA 60 LQDSSKRKQL 70 VSDGLLDSVP 80 GVKRRRLIPE 90 ALLAGMRNRE 100 NSSPCQGNGE 110 QAGRGRSLGN 120 VWPGEEEPCN 130 DATTPSYKKP 140 LYGISHKIME 150 KKNPPSGDLL 160 NVYELFEKAN 170 ASNSPSSLRL 180 LNEPQKRDCG 190 STGAGTDNDP 200 NIYFLIQKMF 210 YMLNTLTSNM 220 SQLHSKVDLL 230 SLEVSRIKKQ 240 VSPTEMVAKF 250 QPPPEYQLTA 260 AELKQIVDQS 270 LSGGDLACRL 280 LVQLFPELFS 290 DVDFSRGCSA 300 CGFAAKRKLE 310 SLHLQLIRNY 320 VEVYYPSVKD 330 TAVWQAECLP 340 QLNDFFSRFW 350 AQREMEDSQP 360 SGQVASFFEA 370 EQVDPGHFLD 380 NKDQEEALSL 390 DRSSTIASDH 400 VVDTQDLTEF 410 LDEASSPGEF 420 AVFLLHRLFP 430 ELFDHRKLGE 440 QYSCYGDGGK 450 QELDPQRLQI 460 IRNYTEIYFP 470 DMQEEEAWLQ 480 QCAQRINDEL 490 EGLGLDAGSE 500 GDPPRDDCYD 510 SSSLPDDISV 520 VKVEDSFEGE 530 RPGRRSKKIW 540 LVPIDFDKLE 550 IPQPDFEVPG 560 ADCLLSKEQL 570 RSIYESSLSI 580 GNFASRLLVH 590 LFPELFTHEN 600 LRKQYNCSGS 610 LGKKQLDPSR 620 IKLIRHYVQL 630 LYPRAKNDRV 640 WTLEFVGKLD 650 ERCRRRDTEQ 660 RRSYQQQRKV 670 HVPGPECRDL 680 TSYAINPERF 690 REEFEGPPLP 700 PERSSKDFCK 710 IPLDELVVPS 720 PDFPVPSPYL 730 LSDKEVREIV 740 QQSLSVGNFA 750 ARLLVRLFPE 760 LFTAENLRLQ 770 YNHSGACNKK 780 QLDPTRLRLI 790 RHYVEAVYPV 800 EKMEEVWHYE 810 CIPSIDERCR 820 RPNRKKCDIL KKAKKVEK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0000182 rDNA binding
Biological Process GO:0006346 DNA methylation-dependent constitutive heterochromatin formation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1903580 positive regulation of ATP metabolic process
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0000183 rDNA heterochromatin formation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.