Search Results
Overview
| Uniprot ID | Q5T655 |
|---|---|
| Protein Name | Cilia- and flagella-associated protein 58 |
| Gene Name | CFAP58 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 255 | KSKEELQKLEQQLKE |
Function
Has an essential role in the assembly and organization of the sperm flagellar axoneme (PubMed:32791035). Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (By similarity)
Protein Sequence
10
MAEEKGGKQV
20
LEESAFEEME
30
RDFQGVLHEL
40
SGDKSLEKFR
50
IEYERLHAVM
60
KKSYDNEKRL
70
MAKCRELNAE
80
IVVNSAKVAT
90
ALKLSQDDQT
100
TIASLKKEIE
110
KAWKMVDSAY
120
DKEQKAKETI
130
LALKEEIVNL
140
TKLVEQGSGL
150
SMDQHSNIRD
160
LLRFKEEVTK
170
ERDQLLSEVV
180
KLRESLAQTT
190
EQQQETERSK
200
EEAEHAISQF
210
QQEIQQRQNE
220
ASREFRKKEK
230
LEKELKQIQA
240
DMDSRQTEIK
250
ALQQYVQKSK
260
EELQKLEQQL
270
KEQKILNERA
280
AKELEQFQMR
290
NAKLQQENEQ
300
HSLVCEQLSQ
310
ENQQKALELK
320
AKEEEVHQMR
330
LDIGKLNKIR
340
EQIHKKLHHT
350
EDQKAEVEQH
360
KETLKNQIVG
370
LEREVEASKK
380
QAELDRKAMD
390
ELLRERDILN
400
KNMLKAVNAT
410
QKQTDLVKLH
420
EQAKRNLEGE
430
IQNYKDEAQK
440
QRKIIFHLEK
450
ERDRYINQAS
460
DLTQKVLMNM
470
EDIKVRETQI
480
FDYRKKIAES
490
EIKLKQQQNL
500
YEAVRSDRNL
510
YSKNLVEAQD
520
EITDMKRKLK
530
IMIHQVDELK
540
EDISAKESAL
550
VKLHLEQQRI
560
EKEKETLKAE
570
LQKLRQQALE
580
TKHFIEKQEA
590
EERKLLRIIA
600
EADGERLRQK
610
KELDQVISER
620
DILGSQLVRR
630
NDELALLYEK
640
IKIQQSVLNK
650
GESQYNQRLE
660
DMRILRLEIK
670
KLRREKGILA
680
RSMANVEELR
690
QEFFHMQREL
700
LKERTRCRAL
710
EEELENPLNV
720
HRWRKLEASD
730
PNAYELIQKI
740
HTLQKRLISK
750
TEEVVEKELL
760
LQEKEKLYME
770
LKHVLARQPG
780
PEAAEQLKLY
790
RRTLHDKKQQ
800
LKVLSSELNM
810
YEVQSKEYKY
820
EVEKLTNELQ
830
NLKKKYLAQK
840
RKEQLQKNKD
850
TAPMDNTFLM
860
VKPNGPGFTG
870
GGFPLRSTKM
TF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0097228 | sperm principal piece |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:0120229 | protein localization to motile cilium |
| Biological Process | GO:0007288 | sperm axoneme assembly |
| Biological Process | GO:0120316 | sperm flagellum assembly |
| Biological Process | GO:0120317 | sperm mitochondrial sheath assembly |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.