Search Results

Overview

Uniprot IDQ5T6F2
Protein NameUbiquitin-associated protein 2
Gene NameUBAP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1103 QPSSLQPKSQASKPA
248 NKSSYGLKGAWKNSV
993 GSSQAPNKSAGSGPG

Function

Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050)

Protein Sequence

10 MMTSVSSDHC 20 RGAREKPQIS 30 AAQSTQPQKQ 40 VVQATAEQMR 50 LAQVIFDKND 60 SDFEAKVKQL 70 MEVTGKNQDE 80 CIVALHDCNG 90 DVNKAINILL 100 EGNSDTTSWE 110 TVGCKKKNFA 120 KENSENKENR 130 EKKSEKESSR 140 GRGNNNRKGR 150 GGNRGREFRG 160 EENGIDCNQV 170 DKPSDRGKRA 180 RGRGFGRGRG 190 RGAGRFSTQG 200 MGTFNPADYS 210 DSTSTDVCGT 220 KLVVWEAAQN 230 GADEGTELAS 240 NTHNIAQDLS 250 NKSSYGLKGA 260 WKNSVEEWTT 270 EDWTEDLSET 280 KVFTASSAPA 290 ENHILPGQSI 300 DLVALLQKPV 310 PHSQASEANS 320 FETSQQQGFG 330 QALVFTNSQH 340 NNQMAPGTGS 350 STAVNSCSPQ 360 SLSSVLGSGF 370 GELAPPKMAN 380 ITSSQILDQL 390 KAPSLGQFTT 400 TPSTQQNSTS 410 HPTTTTSWDL 420 KPPTSQSSVL 430 SHLDFKSQPE 440 PSPVLSQLSQ 450 RQQHQSQAVT 460 VPPPGLESFP 470 SQAKLRESTP 480 GDSPSTVNKL 490 LQLPSTTIEN 500 ISVSVHQPQP 510 KHIKLAKRRI 520 PPASKIPASA 530 VEMPGSADVT 540 GLNVQFGALE 550 FGSEPSLSEF 560 GSAPSSENSN 570 QIPISLYSKS 580 LSEPLNTSLS 590 MTSAVQNSTY 600 TTSVITSCSL 610 TSSSLNSASP 620 VAMSSSYDQS 630 SVHNRIPYQS 640 PVSSSESAPG 650 TIMNGHGGGR 660 SQQTLDTPKT 670 TGPPSALPSV 680 SSLPSTTSCT 690 ALLPSTSQHT 700 GDLTSSPLSQ 710 LSSSLSSHQS 720 SLSAHAALSS 730 STSHTHASVE 740 SASSHQSSAT 750 FSTAATSVSS 760 SASSGASLSS 770 SMNTANSLCL 780 GGTPASASSS 790 SSRAAPLVTS 800 GKAPPNLPQG 810 VPPLLHNQYL 820 VGPGGLLPAY 830 PIYGYDELQM 840 LQSRLPVDYY 850 GIPFAAPTAL 860 ASRDGSLANN 870 PYPGDVTKFG 880 RGDSASPAPA 890 TTPAQPQQSQ 900 SQTHHTAQQP 910 FVNPALPPGY 920 SYTGLPYYTG 930 MPSAFQYGPT 940 MFVPPASAKQ 950 HGVNLSTPTP 960 PFQQASGYGQ 970 HGYSTGYDDL 980 TQGTAAGDYS 990 KGGYAGSSQA 1000 PNKSAGSGPG 1010 KGVSVSSSTT 1020 GLPDMTGSVY 1030 NKTQTFDKQG 1040 FHAGTPPPFS 1050 LPSVLGSTGP 1060 LASGAAPGYA 1070 PPPFLHILPA 1080 HQQPHSQLLH 1090 HHLPQDAQSG 1100 SGQRSQPSSL 1110 QPKSQASKPA YGNSPYWTN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0061484 hematopoietic stem cell homeostasis
Biological Process GO:0010468 regulation of gene expression

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.