Search Results

Overview

Uniprot ID	Q5T6S3
Protein Name	PHD finger protein 19
Gene Name	PHF19
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
23	ATSHLPNKGALAKVK
28	PNKGALAKVKNNFKD

Function

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832)

Protein Sequence

10 MENRALDPGT 20 RDSYGATSHL 30 PNKGALAKVK 40 NNFKDLMSKL 50 TEGQYVLCRW 60 TDGLYYLGKI 70 KRVSSSKQSC 80 LVTFEDNSKY 90 WVLWKDIQHA 100 GVPGEEPKCN 110 ICLGKTSGPL 120 NEILICGKCG 130 LGYHQQCHIP 140 IAGSADQPLL 150 TPWFCRRCIF 160 ALAVRKGGAL 170 KKGAIARTLQ 180 AVKMVLSYQP 190 EELEWDSPHR 200 TNQQQCYCYC 210 GGPGEWYLRM 220 LQCYRCRQWF 230 HEACTQCLNE 240 PMMFGDRFYL 250 FFCSVCNQGP 260 EYIERLPLRW 270 VDVVHLALYN 280 LGVQSKKKYF 290 DFEEILAFVN 300 HHWELLQLGK 310 LTSTPVTDRG 320 PHLLNALNSY 330 KSRFLCGKEI 340 KKKKCIFRLR 350 IRVPPNPPGK 360 LLPDKGLLPN 370 ENSASSELRK 380 RGKSKPGLLP 390 HEFQQQKRRV 400 YRRKRSKFLL 410 EDAIPSSDFT 420 SAWSTNHHLA 430 SIFDFTLDEI 440 QSLKSASSGQ 450 TFFSDVDSTD 460 AASTSGSAST 470 SLSYDSRWTV 480 GSRKRKLAAK 490 AYMPLRAKRW 500 AAELDGRCPS 510 DSSAEGASVP 520 ERPDEGIDSH 530 TFESISEDDS 540 SLSHLKSSIT 550 NYFGAAGRLA 560 CGEKYQVLAR 570 RVTPEGKVQY 580 LVEWEGTTPY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035098	ESC/E(Z) complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0140003	histone H3K36me3 reader activity
Molecular Function	GO:0140002	histone H3K4me3 reader activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0048863	stem cell differentiation
Biological Process	GO:0019827	stem cell population maintenance

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.