Search Results

Overview

Uniprot ID	Q5T890
Protein Name	DNA excision repair protein ERCC-6-like 2
Gene Name	ERCC6L2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1021	FKRIKETKKELHNSP
1022	KRIKETKKELHNSPK
1029	KELHNSPKTMNKTNQ

Function

Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (By similarity). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair (PubMed:24507776, PubMed:37014751). Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (PubMed:37014751)

Protein Sequence

10 MQPGSAPPPG 20 RMDPSAPQPR 30 AETSGKDIWH 40 PGERCLAPSP 50 DNGKLCEASI 60 KSITVDENGK 70 SFAVVLYADF 80 QERKIPLKQL 90 QEVKFVKDCP 100 RNLIFDDEDL 110 EKPYFPNRKF 120 PSSSVAFKLS 130 DNGDSIPYTI 140 NRYLRDYQRE 150 GTRFLYGHYI 160 HGGGCILGDD 170 MGLGKTVQVI 180 SFLAAVLHKK 190 GTREDIENNM 200 PEFLLRSMKK 210 EPLSSTAKKM 220 FLIVAPLSVL 230 YNWKDELDTW 240 GYFRVTVLHG 250 NRKDNELIRV 260 KQRKCEIALT 270 TYETLRLCLD 280 ELNSLEWSAV 290 IVDEAHRIKN 300 PKARVTEVMK 310 ALKCNVRIGL 320 TGTILQNNMK 330 ELWCVMDWAV 340 PGLLGSGTYF 350 KKQFSDPVEH 360 GQRHTATKRE 370 LATGRKAMQR 380 LAKKMSGWFL 390 RRTKTLIKDQ 400 LPKKEDRMVY 410 CSLTDFQKAV 420 YQTVLETEDV 430 TLILQSSEPC 440 TCRSGQKRRN 450 CCYKTNSHGE 460 TVKTLYLSYL 470 TVLQKVANHV 480 ALLQAASTSK 490 QQETLIKRIC 500 DQVFSRFPDF 510 VQKSKDAAFE 520 TLSDPKYSGK 530 MKVLQQLLNH 540 CRKNRDKVLL 550 FSFSTKLLDV 560 LQQYCMASGL 570 DYRRLDGSTK 580 SEERLKIVKE 590 FNSTQDVNIC 600 LVSTMAGGLG 610 LNFVGANVVV 620 LFDPTWNPAN 630 DLQAIDRAYR 640 IGQCRDVKVL 650 RLISLGTVEE 660 IMYLRQIYKQ 670 QLHCVVVGSE 680 NAKRYFEAVQ 690 GSKEHQGELF 700 GIHNLFKFRS 710 QGSCLTKDIL 720 EREGQVEAGI 730 MTATTWLKEG 740 PPAHKLEMPR 750 QPDCQECRGT 760 EQAAEPLAKE 770 ACDLCSDFSD 780 EEPVGATGIK 790 TAKNKAPDSS 800 KASSSPGQLT 810 LLQCGFSKLL 820 ETKCKAVEDS 830 DGNTASDDES 840 SDEQPTCLST 850 EAKDAGCEKN 860 QDSLGTSKHQ 870 KLDNILNPKE 880 KHIFYKSEKI 890 LEQNISSKSD 900 EKKIKNTDKH 910 CILQNVTESE 920 DSDVICPTQY 930 TTERFPDNSI 940 RFKPPLEGSE 950 DSETEHTVKT 960 RNNDNSRNTD 970 DKRNGIISKK 980 LSPENTTLKS 990 ILKRKGTSDI 1000 SDESDDIEIS 1010 SKSRVRKRAS 1020 SLRFKRIKET 1030 KKELHNSPKT 1040 MNKTNQVYAA 1050 NEDHNSQFID 1060 DYSSSDESLS 1070 VSHFSFSKQS 1080 HRPRTIRDRT 1090 SFSSKLPSHN 1100 KKNSTFIPRK 1110 PMKCSNEKVV 1120 NQEQSYESMD 1130 KFLDGVQEVA 1140 YIHSNQNVIG 1150 SSKAENHMSR 1160 WAAHDVFELK 1170 QFSQLPANIA 1180 VCSSKTYKEK 1190 VDADTLPHTK 1200 KGQQPSEGSI 1210 SLPLYISNPV 1220 NQKKKKVYHT 1230 NQTTFIIGET 1240 PKGIRRKQFE 1250 EMASYFNSSS 1260 VNEFAKHITN 1270 ATSEERQKML 1280 RDFYASQYPE 1290 VKEFFVDSVS 1300 QFNNSSFEKG 1310 EQRTRKKSDK 1320 RESLIKPRLS 1330 DSETLSFKDS 1340 TNKISQVCSL 1350 KTYKRKSVKF 1360 QNHISYREEV 1370 FFNDAETKKS 1380 PVSSTQEIDS 1390 GKNSQASEDT 1400 VTSRSLNSES 1410 ETRERRLENT 1420 MKDQQDLTRT 1430 GISRKEPLLK 1440 LENKKIENPV 1450 LENTSVISLL 1460 GDTSILDDLF 1470 KSHGNSPTQL 1480 PKKVLSGPME 1490 KAKQRPKDFW 1500 DILNEQNDES 1510 LSKLTDLAVI 1520 ETLCEKAPLA 1530 APFKRREEPA 1540 TSLWKSNEKF 1550 LWKKFSPSDT 1560 DENATNTQST T

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0000775	chromosome, centromeric region
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0004386	helicase activity
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0034614	cellular response to reactive oxygen species
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0097680	double-strand break repair via classical nonhomologous end joining
Biological Process	GO:0036297	interstrand cross-link repair

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.