Search Results

Overview

Uniprot IDQ5TB80
Protein NameCentrosomal protein of 162 kDa
Gene NameCEP162
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
684 SSFEETNKKQRWLHF

Function

Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules

Protein Sequence

10 MANCSQEELD 20 EEFEQFMKEL 30 SDDSFENSDK 40 TARQSKKEMK 50 KKDTVPWWIT 60 EDDFKDDGLL 70 GTNVSYLKTK 80 KTSQPVMEIE 90 EESAEKIQFL 100 KSSGTSLLST 110 DSLETNELVV 120 SELNHSSLGV 130 GLDTLEEQEE 140 KEQFFARLEK 150 GLTSSIDYSR 160 LNKELDSNDS 170 THFKALHSNQ 180 ANAELTDDEH 190 ENESKHEELA 200 ENYSDDFEDE 210 YVGAPLTTKD 220 EEMPSKENSK 230 SEKISVPKQE 240 EEKTGMLANV 250 VLLDSLDSVA 260 EVNLDEQDKI 270 TPKPRCLPEM 280 TENEMTGTGV 290 SYGQSSSDVE 300 ALHQAYCHIA 310 HSLGDEDKQK 320 IESNTVEDIK 330 SSVKGHPQEN 340 EENSKNISTM 350 ESDLPTVEEL 360 MKPIRIDSFG 370 ISGFDLQPVS 380 SEKVAERKET 390 EFFSSLPLKM 400 NPNILSQDSQ 410 HVNLFFDKND 420 ENVILQKTTN 430 ESMENSCPQV 440 TEVTATEEHV 450 DKMYLNILRK 460 KITVNSSSLS 470 QDDKINKTYR 480 SQLSSEEEGA 490 VMGKQVPYKK 500 ARSAPPLLKR 510 KPQSGLYASV 520 RSSGYGKPSS 530 PLKMFSTLEK 540 KTSEDIIKSK 550 NLRSISTSNQ 560 PRKKEILSGT 570 KLIKPAALDK 580 PAHKTESCLS 590 TRKKSENPTE 600 TDSCIQFQTD 610 SLGYCGENKE 620 KKLLMFKRVQ 630 EAEDKWRGAQ 640 ALIEQIKATF 650 SEKEKELENK 660 LEELKKQQEK 670 ELFKLNQDNY 680 ILQAKLSSFE 690 ETNKKQRWLH 700 FGEAADPVTG 710 EKLKQIQKEI 720 QEQETLLQGY 730 QQENERLYNQ 740 VKDLQEQNKK 750 NEERMFKENQ 760 SLFSEVASLK 770 EQMHKSRFLS 780 QVVEDSEPTR 790 NQNFTDLLAE 800 LRMAQKEKDS 810 LLEDIKRLKQ 820 DKQALEVDFE 830 KMKKERDQAK 840 DQIAYVTGEK 850 LYEIKILEET 860 HKQEISRLQK 870 RLQWYAENQE 880 LLDKDALRLR 890 EANEEIEKLK 900 LEIEKLKAES 910 GNPSIRQKIR 920 LKDKAADAKK 930 IQDLERQVKE 940 MEGILKRRYP 950 NSLPALILAA 960 SAAGDTVDKN 970 TVEFMEKRIK 980 KLEADLEGKD 990 EDAKKSLRTM 1000 EQQFQKMKIQ 1010 YEQRLEQQEQ 1020 LLACKLNQHD 1030 SPRIKALEKE 1040 LDDIKEAHQI 1050 TVRNLEAEID 1060 VLKHQNAELD 1070 VKKNDKDDED 1080 FQSIEFQVEQ 1090 AHAKAKLVRL 1100 NEELAAKKRE 1110 IQDLSKTVER 1120 LQKDRRMMLS 1130 NQNSKGREEM 1140 SAKRAKKDVL 1150 HSSKGNANSF 1160 PGTLDSKLYQ 1170 PHTFTDSHVS 1180 EVLQENYRLK 1190 NELEGLISEK 1200 NELKMKSEAV 1210 MNQFENSMRR 1220 VKEDTAAHIA 1230 SLKASHQREI 1240 EKLLCQNAVE 1250 NSSSKVAELN 1260 RKIATQEVLI 1270 RHFQSQVNEL 1280 QSKQESLVVS 1290 EVREEILQKE 1300 ITKLLEELRE 1310 AKENHTPEMK 1320 HFVGLEKKIK 1330 QMEMRHAQRE 1340 QELQQIIQQT 1350 HQVVETEQNK 1360 EVEKWKRLAQ 1370 LKNRELEKFR 1380 TELDSILDVL 1390 RELHRQGVVV 1400 PVAFADEMNA PEY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005879 axonemal microtubule
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005814 centriole
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005819 spindle
Biological Process GO:0060271 cilium assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.