Search Results

Overview

Uniprot IDQ5TBB1
Protein NameRibonuclease H2 subunit B
Gene NameRNASEH2B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
247 SLPNPPSKKIKLSDE
248 LPNPPSKKIKLSDEP
264 EAKEDYTKFNTKDLK
268 DYTKFNTKDLKTEKK
278 KTEKKNSKMTAAQKA
284 SKMTAAQKALAKVDK
304 IDTFFGVKNKKKIGK

Function

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

Protein Sequence

10 MAAGVDCGDG 20 VGARQHVFLV 30 SEYLKDASKK 40 MKNGLMFVKL 50 VNPCSGEGAI 60 YLFNMCLQQL 70 FEVKVFKEKH 80 HSWFINQSVQ 90 SGGLLHFATP 100 VDPLFLLLHY 110 LIKADKEGKF 120 QPLDQVVVDN 130 VFPNCILLLK 140 LPGLEKLLHH 150 VTEEKGNPEI 160 DNKKYYKYSK 170 EKTLKWLEKK 180 VNQTVAALKT 190 NNVNVSSRVQ 200 STAFFSGDQA 210 STDKEEDYIR 220 YAHGLISDYI 230 PKELSDDLSK 240 YLKLPEPSAS 250 LPNPPSKKIK 260 LSDEPVEAKE 270 DYTKFNTKDL 280 KTEKKNSKMT 290 AAQKALAKVD 300 KSGMKSIDTF 310 FGVKNKKKIG KV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032299 ribonuclease H2 complex
Biological Process GO:0006298 mismatch repair
Biological Process GO:0006401 RNA catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.