Search Results
Overview
| Uniprot ID | Q5TCH4 |
|---|---|
| Protein Name | Cytochrome P450 4A22 |
| Gene Name | CYP4A22 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 499 | ARLVLKSKNGIHLRL |
Function
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis
Protein Sequence
10
MSVSVLSPSR
20
RLGGVSGILQ
30
VTSLLILLLL
40
LIKAAQLYLH
50
RQWLLKALQQ
60
FPCPPSHWLF
70
GHIQEFQHDQ
80
ELQRIQERVK
90
TFPSACPYWI
100
WGGKVRVQLY
110
DPDYMKVILG
120
RSDPKSHGSY
130
KFLAPRIGYG
140
LLLLNGQTWF
150
QHRRMLTPAF
160
HNDILKPYVG
170
LMADSVRVML
180
DKWEELLGQD
190
SPLEVFQHVS
200
LMTLDTIMKS
210
AFSHQGSIQV
220
DRNSQSYIQA
230
ISDLNSLVFC
240
CMRNAFHEND
250
TIYSLTSAGR
260
WTHRACQLAH
270
QHTDQVIQLR
280
KAQLQKEGEL
290
EKIKRKRHLD
300
FLDILLLAKM
310
ENGSILSDKD
320
LRAEVDTFMF
330
EGHDTTASGI
340
SWILYALATH
350
PKHQERCREE
360
IHGLLGDGAS
370
ITWNHLDQMP
380
YTTMCIKEAL
390
RLYPPVPGIG
400
RELSTPVTFP
410
DGRSLPKGIM
420
VLLSIYGLHH
430
NPKVWPNLEV
440
FDPSRFAPGS
450
AQHSHAFLPF
460
SGGSRNCIGK
470
QFAMNQLKVA
480
RALTLLRFEL
490
LPDPTRIPIP
500
MARLVLKSKN
510
GIHLRLRRLP
NPCEDKDQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0103002 | 16-hydroxypalmitate dehydrogenase activity |
| Molecular Function | GO:0018685 | alkane 1-monooxygenase activity |
| Molecular Function | GO:0008391 | arachidonate monooxygenase activity |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0102033 | long-chain fatty acid omega-hydroxylase activity |
| Molecular Function | GO:0140981 | medium-chain fatty acid omega-hydroxylase activity |
| Biological Process | GO:0019369 | arachidonate metabolic process |
| Biological Process | GO:0046456 | icosanoid biosynthetic process |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0048252 | lauric acid metabolic process |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0002933 | lipid hydroxylation |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.