Search Results

Overview

Uniprot IDQ5TCY1
Protein NameTau-tubulin kinase 1
Gene NameTTBK1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
82 KMEVAVLKKLQGKDH

Function

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU

Protein Sequence

10 MQCLAAALKD 20 ETNMSGGGEQ 30 ADILPANYVV 40 KDRWKVLKKI 50 GGGGFGEIYE 60 AMDLLTRENV 70 ALKVESAQQP 80 KQVLKMEVAV 90 LKKLQGKDHV 100 CRFIGCGRNE 110 KFNYVVMQLQ 120 GRNLADLRRS 130 QPRGTFTLST 140 TLRLGKQILE 150 SIEAIHSVGF 160 LHRDIKPSNF 170 AMGRLPSTYR 180 KCYMLDFGLA 190 RQYTNTTGDV 200 RPPRNVAGFR 210 GTVRYASVNA 220 HKNREMGRHD 230 DLWSLFYMLV 240 EFAVGQLPWR 250 KIKDKEQVGM 260 IKEKYEHRML 270 LKHMPSEFHL 280 FLDHIASLDY 290 FTKPDYQLIM 300 SVFENSMKER 310 GIAENEAFDW 320 EKAGTDALLS 330 TSTSTPPQQN 340 TRQTAAMFGV 350 VNVTPVPGDL 360 LRENTEDVLQ 370 GEHLSDQENA 380 PPILPGRPSE 390 GLGPSPHLVP 400 HPGGPEAEVW 410 EETDVNRNKL 420 RINIGKSPCV 430 EEEQSRGMGV 440 PSSPVRAPPD 450 SPTTPVRSLR 460 YRRVNSPESE 470 RLSTADGRVE 480 LPERRSRMDL 490 PGSPSRQACS 500 SQPAQMLSVD 510 TGHADRQASG 520 RMDVSASVEQ 530 EALSNAFRSV 540 PLAEEEDFDS 550 KEWVIIDKET 560 ELKDFPPGAE 570 PSTSGTTDEE 580 PEELRPLPEE 590 GEERRRLGAE 600 PTVRPRGRSM 610 QALAEEDLQH 620 LPPQPLPPQL 630 SQGDGRSETS 640 QPPTPGSPSH 650 SPLHSGPRPR 660 RRESDPTGPQ 670 RQVFSVAPPF 680 EVNGLPRAVP 690 LSLPYQDFKR 700 DLSDYRERAR 710 LLNRVRRVGF 720 SHMLLTTPQV 730 PLAPVQPQAN 740 GKEEEEEEEE 750 DEEEEEEDEE 760 EEEEEEEEEE 770 EEEEEEEEEE 780 EAAAAVALGE 790 VLGPRSGSSS 800 EGSERSTDRS 810 QEGAPSTLLA 820 DDQKESRGRA 830 SMADGDLEPE 840 EGSKTLVLVS 850 PGDMKKSPVT 860 AELAPDPDLG 870 TLAALTPQHE 880 RPQPTGSQLD 890 VSEPGTLSSV 900 LKSEPKPPGP 910 GAGLGAGTVT 920 TGVGGVAVTS 930 SPFTKVERTF 940 VHIAEKTHLN 950 VMSSGGQALR 960 SEEFSAGGEL 970 GLELASDGGA 980 VEEGARAPLE 990 NGLALSGLNG 1000 AEIEGSALSG 1010 APRETPSEMA 1020 TNSLPNGPAL 1030 ADGPAPVSPL 1040 EPSPEKVATI 1050 SPRRHAMPGS 1060 RPRSRIPVLL 1070 SEEDTGSEPS 1080 GSLSAKERWS 1090 KRARPQQDLA 1100 RLVMEKRQGR 1110 LLLRLASGAS 1120 SSSSEEQRRA 1130 SETLSGTGSE 1140 EDTPASEPAA 1150 ALPRKSGRAA 1160 ATRSRIPRPI 1170 GLRMPMPVAA 1180 QQPASRSHGA 1190 APALDTAITS 1200 RLQLQTPPGS 1210 ATAADLRPKQ 1220 PPGRGLGPGR 1230 AQAGARPPAP 1240 RSPRLPASTS 1250 AARNASASPR 1260 SQSLSRRESP 1270 SPSHQARPGV 1280 PPPRGVPPAR 1290 AQPDGTPSPG 1300 GSKKGPRGKL 1310 QAQRATTKGR 1320 AGGAEGRAGA R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0004713 protein tyrosine kinase activity
Molecular Function GO:0048156 tau protein binding
Molecular Function GO:0050321 tau-protein kinase activity
Biological Process GO:0007611 learning or memory
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0061890 positive regulation of astrocyte activation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1903980 positive regulation of microglial cell activation
Biological Process GO:0032273 positive regulation of protein polymerization
Biological Process GO:0007165 signal transduction
Biological Process GO:0021762 substantia nigra development

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.