Search Results

Overview

Uniprot ID	Q5TEC6
Protein Name	Histone H3-7
Gene Name	H3-7
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
15	ARKSTGGKAPRKQLA
24	PRKQLATKAARKSAP
28	LATKAARKSAPATGG
57	REIRRYQKSTELLIR

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Protein Sequence

10 MARTKQTARK 20 STGGKAPRKQ 30 LATKAARKSA 40 PATGGVKKPH 50 RYRPGTVALR 60 EIRRYQKSTE 70 LLIRKLPFQR 80 LVREIAQEFK 90 TDLRFQSSAV 100 MALQEAREAY 110 LVGLFEDTNL 120 CAIHAKRVTI 130 MPKDIQLVSR IRGERA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0043505	CENP-A containing nucleosome
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0031492	nucleosomal DNA binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0030527	structural constituent of chromatin
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0051382	kinetochore assembly
Biological Process	GO:0007080	mitotic metaphase chromosome alignment

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.