Search Results

Overview

Uniprot ID	Q5TGY3
Protein Name	Transcription factor Gibbin
Gene Name	AHDC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1418	ELRPPPTKLAACEPL

Function

Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237)

Protein Sequence

10 MRVKPQGLVV 20 TSSAVCSSPD 30 YLREPKYYPG 40 GPPTPRPLLP 50 TRPPASPPDK 60 AFSTHAFSEN 70 PRPPPRRDPS 80 TRRPPVLAKG 90 DDPLPPRAAR 100 PVSQARCPTP 110 VGDGSSSRRC 120 WDNGRVNLRP 130 VVQLIDIMKD 140 LTRLSQDLQH 150 SGVHLDCGGL 160 RLSRPPAPPP 170 GDLQYSFFSS 180 PSLANSIRSP 190 EERATPHAKS 200 ERPSHPLYEP 210 EPEPRDSPQP 220 GQGHSPGATA 230 AATGLPPEPE 240 PDSTDYSELA 250 DADILSELAS 260 LTCPEAQLLE 270 AQALEPPSPE 280 PEPQLLDPQP 290 RFLDPQALEP 300 LGEALELPPL 310 QPLADPLGLP 320 GLALQALDTL 330 PDSLESQLLD 340 PQALDPLPKL 350 LDVPGRRLEP 360 QQPLGHCPLA 370 EPLRLDLCSP 380 HGPPGPEGHP 390 KYALRRTDRP 400 KILCRRRKAG 410 RGRKADAGPE 420 GRLLPLPMPT 430 GLVAALAEPP 440 PPPPPPPPAL 450 PGPGPVSVPE 460 LKPESSQTPV 470 VSTRKGKCRG 480 VRRMVVKMAK 490 IPVSLGRRNK 500 TTYKVSSLSS 510 SLSVEGKELG 520 LRVSAEPTPL 530 LKMKNNGRNV 540 VVVFPPGEMP 550 IILKRKRGRP 560 PKNLLLGPGK 570 PKEPAVVAAE 580 AATVAAATMA 590 MPEVKKRRRR 600 KQKLASPQPS 610 YAADANDSKA 620 EYSDVLAKLA 630 FLNRQSQCAG 640 RCSPPRCWTP 650 SEPESVHQAP 660 DTQSISHFLH 670 RVQGFRRRGG 680 KAGGFGGRGG 690 GHAAKSARCS 700 FSDFFEGIGK 710 KKKVVAVAAA 720 GVGGPGLTEL 730 GHPRKRGRGE 740 VDAVTGKPKR 750 KRRSRKNGTL 760 FPEQVPSGPG 770 FGEAGAEWAG 780 DKGGGWAPHH 790 GHPGGQAGRN 800 CGFQGTEARA 810 FASTGLESGA 820 SGRGSYYSTG 830 APSGQTELSQ 840 ERQNLFTGYF 850 RSLLDSDDSS 860 DLLDFALSAS 870 RPESRKASGT 880 YAGPPTSALP 890 AQRGLATFPS 900 RGAKASPVAV 910 GSSGAGADPS 920 FQPVLSARQT 930 FPPGRAASYG 940 LTPAASDCRA 950 AETFPKLVPP 960 PSAMARSPTT 970 HPPANTYLPQ 980 YGGYGAGQSV 990 FAPTKPFTGQ 1000 DCANSKDCSF 1010 AYGSGNSLPA 1020 SPSSAHSAGY 1030 APPPTGGPCL 1040 PPSKASFFSS 1050 SEGAPFSGSA 1060 PTPLRCDSRA 1070 STVSPGGYMV 1080 PKGTTASATS 1090 AASAASSSSS 1100 SFQPSPENCR 1110 QFAGASQWPF 1120 RQGYGGLDWA 1130 SEAFSQLYNP 1140 SFDCHVSEPN 1150 VILDISNYTP 1160 QKVKQQTAVS 1170 ETFSESSSDS 1180 TQFNQPVGGG 1190 GFRRANSEAS 1200 SSEGQSSLSS 1210 LEKLMMDWNE 1220 ASSAPGYNWN 1230 QSVLFQSSSK 1240 PGRGRRKKVD 1250 LFEASHLGFP 1260 TSASAAASGY 1270 PSKRSTGPRQ 1280 PRGGRGGGAC 1290 SAKKERGGAA 1300 AKAKFIPKPQ 1310 PVNPLFQDSP 1320 DLGLDYYSGD 1330 SSMSPLPSQS 1340 RAFGVGERDP 1350 CDFIGPYSMN 1360 PSTPSDGTFG 1370 QGFHCDSPSL 1380 GAPELDGKHF 1390 PPLAHPPTVF 1400 DAGLQKAYSP 1410 TCSPTLGFKE 1420 ELRPPPTKLA 1430 ACEPLKHGLQ 1440 GASLGHAAAA 1450 QAHLSCRDLP 1460 LGQPHYDSPS 1470 CKGTAYWYPP 1480 GSAARSPPYE 1490 GKVGTGLLAD 1500 FLGRTEAACL 1510 SAPHLASPPA 1520 TPKADKEPLE 1530 MARPPGPPRG 1540 PAAAAAGYGC 1550 PLLSDLTLSP 1560 VPRDSLLPLQ 1570 DTAYRYPGFM 1580 PQAHPGLGGG 1590 PKSGFLGPMA 1600 EPHPEDTFTV TSL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0140585	promoter-enhancer loop anchoring activity
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0001707	mesoderm formation
Biological Process	GO:0043589	skin morphogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.