Search Results

Overview

Uniprot IDQ5THJ4
Protein NameIntermembrane lipid transfer protein VPS13D
Gene NameVPS13D
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
4004 LSVFTSNKLPLDLKA

Function

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis

Protein Sequence

10 MLEGLVAWVL 20 NTYLGKYVNN 30 LNTDQLSVAL 40 LKGAVELENL 50 PLKKDALKEL 60 ELPFEVKAGF 70 IGKVTLQIPF 80 YRPHVDPWVI 90 SISSLHLIGA 100 PEKIQDFNDE 110 KEKLLERERK 120 KALLQALEEK 130 WKNDRQQKGE 140 SYWYSVTASV 150 VTRIVENIEL 160 KIQDVHLRFE 170 DGVTNPSHPF 180 AFGICIKNVS 190 MQNAVNEPVQ 200 KLMRKKQLDV 210 AEFSIYWDVD 220 CTLLGDLPQM 230 ELQEAMARSM 240 ESRSHHYVLE 250 PVFASALLKR 260 NCSKKPLRSR 270 HSPRIDCDIQ 280 LETIPLKLSQ 290 LQYRQIMEFL 300 KELERKERQV 310 KFRRWKPKVA 320 ISKNCREWWY 330 FALNANLYEI 340 REQRKRCTWD 350 FMLHRARDAV 360 SYTDKYFNKL 370 KGGLLSTDDK 380 EEMCRIEEEQ 390 SFEELKILRE 400 LVHDRFHKQE 410 ELAESLREPQ 420 FDSPGACPGA 430 PEPGGGSGML 440 QYLQSWFPGW 450 GGWYGQQTPE 460 GNVVEGLSAE 470 QQEQWIPEEI 480 LGTEEFFDPT 490 ADASCMNTYT 500 KRDHVFAKLN 510 LQLQRGTVTL 520 LHKEQGTPQM 530 NESAFMQLEF 540 SDVKLLAESL 550 PRRNSSLLSV 560 RLGGLFLRDL 570 ATEGTMFPLL 580 VFPNPQKEVG 590 RVSQSFGLQT 600 TSADRSDHYP 610 AADPDGPVFE 620 MLYERNPAHS 630 HFERRLNVST 640 RPLNIIYNPQ 650 AIKKVADFFY 660 KGKVHTSGFG 670 YQSELELRVA 680 EAARRQYNKL 690 KMQTKAEIRQ 700 TLDRLLVGDF 710 IEESKRWTVR 720 LDISAPQVIF 730 PDDFKFKNPV 740 LVVVDLGRML 750 LTNTQDNSRR 760 KSRDGSASEE 770 TQFSDDEYKT 780 PLATPPNTPP 790 PESSSSNGEK 800 TPPFSGVEFS 810 EEQLQAHLMS 820 TKMYERYSLS 830 FMDLQIMVGR 840 VKDNWKHVQD 850 IDVGPTHVVE 860 KFNVHLQLER 870 RLIYTSDPKY 880 PGAVLSGNLP 890 DLKIHINEDK 900 ISALKNCFAL 910 LTTPEMKTSD 920 TQIKEKIFPQ 930 EEQRGSLQDS 940 VMNLTQSIVL 950 LEQHTREVLV 960 ESQLLLAEFK 970 VNCMQLGVES 980 NGRYISVLKV 990 FGTNAHFVKR 1000 PYDAEVSLTV 1010 HGLLLVDTMQ 1020 TYGADFDLLM 1030 ASHKNLSFDI 1040 PTGSLRDSRA 1050 QSPVSGPNVA 1060 HLTDGATLND 1070 RSATSVSLDK 1080 ILTKEQESLI 1090 KLEYQFVSSE 1100 CPSMNLDSTL 1110 QVISLQVNNL 1120 DIILNPETIV 1130 ELIGFLQKSF 1140 PKEKDDLSPQ 1150 PLMTDFERSF 1160 REQGTYQSTY 1170 EQNTEVAVEI 1180 HRLNLLLLRT 1190 VGMANREKYG 1200 RKIATASIGG 1210 TKVNVSMGST 1220 FDMNGSLGCL 1230 QLMDLTQDNV 1240 KNQYVVSIGN 1250 SVGYENIISD 1260 IGYFESVFVR 1270 MEDAALTEAL 1280 SFTFVERSKQ 1290 ECFLNLKMAS 1300 LHYNHSAKFL 1310 KELTLSMDEL 1320 EENFRGMLKS 1330 AATKVTTVLA 1340 TKTAEYSEMV 1350 SLFETPRKTR 1360 EPFILEENEI 1370 YGFDLASSHL 1380 DTVKLILNIN 1390 IESPVVSIPR 1400 KPGSPELLVG 1410 HLGQIFIQNF 1420 VAGDDESRSD 1430 RLQVEIKDIK 1440 LYSLNCTQLA 1450 GREAVGSEGS 1460 RMFCPPSGSG 1470 SANSQEEAHF 1480 TRHDFFESLH 1490 RGQAFHILNN 1500 TTIQFKLEKI 1510 PIERESELTF 1520 SLSPDDLGTS 1530 SIMKIEGKFV 1540 NPVQVVLAKH 1550 VYEQVLQTLD 1560 NLVYSEDLNK 1570 YPASATSSPC 1580 PDSPLPPLST 1590 CGESSVERKE 1600 NGLFSHSSLS 1610 NTSQKSLSVK 1620 EVKSFTQIQA 1630 TFCISELQVQ 1640 LSGDLTLGAQ 1650 GLVSLKFQDF 1660 EVEFSKDHPQ 1670 TLSIQIALHS 1680 LLMEDLLEKN 1690 PDSKYKNLMV 1700 SRGAPKPSSL 1710 AQKEYLSQSC 1720 PSVSNVEYPD 1730 MPRSLPSHME 1740 EAPNVFQLYQ 1750 RPTSASRKKQ 1760 KEVQDKDYPL 1770 TPPPSPTVDE 1780 PKILVGKSKF 1790 DDSLVHINIF 1800 LVDKKHPEFS 1810 SSYNRVNRSI 1820 DVDFNCLDVL 1830 ITLQTWVVIL 1840 DFFGIGSTAD 1850 NHAMRLPPEG 1860 ILHNVKLEPH 1870 ASMESGLQDP 1880 VNTKLDLKVH 1890 SLSLVLNKTT 1900 SELAKANVSK 1910 LVAHLEMIEG 1920 DLALQGSIGS 1930 LSLSDLTCHG 1940 EFYRERFTTS 1950 GEEALIFQTF 1960 KYGRPDPLLR 1970 REHDIRVSLR 1980 MASVQYVHTQ 1990 RFQAEVVAFI 2000 QHFTQLQDVL 2010 GRQRAAIEGQ 2020 TVRDQAQRCS 2030 RVLLDIEAGA 2040 PVLLIPESSR 2050 SNNLIVANLG 2060 KLKVKNKFLF 2070 AGFPGTFSLQ 2080 DKESVPSASP 2090 TGIPKHSLRK 2100 TTSTEEPRGT 2110 HSQGQFTMPL 2120 AGMSLGSLKS 2130 EFVPSTSTKQ 2140 QGPQPTLSVG 2150 QESSSPEDHV 2160 CLLDCVVVDL 2170 QDMDIFAAER 2180 HPREYSKAPE 2190 DSSGDLIFPS 2200 YFVRQTGGSL 2210 LTEPCRLKLQ 2220 VERNLDKEIS 2230 HTVPDISIHG 2240 NLSSVHCSLD 2250 LYKYKLIRGL 2260 LENNLGEPIE 2270 EFMRPYDLQD 2280 PRIHTVLSGE 2290 VYTCMCFLID 2300 MVNVSLELKD 2310 PKRKEGAGSL 2320 ARFDFKKCKL 2330 LYESFSNQTK 2340 SINLVSHSMM 2350 AFDTRYAGQK 2360 TSPGMTNVFS 2370 CIFQPAKNSS 2380 TTQGSIQIEL 2390 HFRSTKDSSC 2400 FTVVLNNLRV 2410 FLIFDWLLLV 2420 HDFLHTPSDI 2430 KKQNHVTPSR 2440 HRNSSSESAI 2450 VPKTVKSGVV 2460 TKRSSLPVSN 2470 ERHLEVKVNV 2480 TGTEFVVIED 2490 VSCFDTNAII 2500 LKGTTVLTYK 2510 PRFVDRPFSG 2520 SLFGIEVFSC 2530 RLGNEHDTAL 2540 SIVDPVQIQM 2550 ELVGNSSYQN 2560 SSGLMDAFNS 2570 EDFPPVLEIQ 2580 LQALDIRLSY 2590 NDVQLFLAIA 2600 KSIPEQANAA 2610 VPDSVALESD 2620 SVGTYLPGAS 2630 RVGEEIREGT 2640 RHTLDPVLEL 2650 QLARLQELGF 2660 SMDDCRKALL 2670 ACQGQLKKAA 2680 SWLFKNAEPL 2690 KSLSLASTSR 2700 DSPGAVAAPL 2710 ISGVEIKAES 2720 VCICFIDDCM 2730 DCDVPLAELT 2740 FSRLNFLQRV 2750 RTSPEGYAHF 2760 TLSGDYYNRA 2770 LSGWEPFIEP 2780 WPCSVSWQQQ 2790 AASRLHPPRL 2800 KLEAKAKPRL 2810 DINITSVLID 2820 QYVSTKESWM 2830 ADYCKDDKDI 2840 ESAKSEDWMG 2850 SSVDPPCFGQ 2860 SLPLVYLRTR 2870 STASLTNLEH 2880 QIYARAEVKT 2890 PKRRQPFVPF 2900 ALRNHTGCTL 2910 WFATLTTTPT 2920 RAALSHSGSP 2930 GVVPEGNGTF 2940 LDDTHNVSEW 2950 REVLTGEEIP 2960 FEFEARGKLR 2970 HRHTHDLRIH 2980 QLQVRVNGWE 2990 QVSPVSVDKV 3000 GTFFRYAAPD 3010 KNSSSSTIGS 3020 PSSRTNIIHP 3030 QVYFSSLPPV 3040 RVVFAVTMEG 3050 SARKVITVRS 3060 ALIVRNRLET 3070 PMELRLDSPS 3080 APDKPVVLPA 3090 IMPGDSFAVP 3100 LHLTSWRLQA 3110 RPKGLGVFFC 3120 KAPIHWTNVV 3130 KTAEISSSKR 3140 ECHSMDTEKS 3150 RFFRFCVAIK 3160 KENYPDYMPS 3170 NIFSDSAKQI 3180 FRQPGHTIYL 3190 LPTVVICNLL 3200 PCELDFYVKG 3210 MPINGTLKPG 3220 KEAALHTADT 3230 SQNIELGVSL 3240 ENFPLCKELL 3250 IPPGTQNYMV 3260 RMRLYDVNRR 3270 QLNLTIRIVC 3280 RAEGSLKIFI 3290 SAPYWLINKT 3300 GLPLIFRQDN 3310 AKTDAAGQFE 3320 EHELARSLSP 3330 LLFCYADKEQ 3340 PNLCTMRIGR 3350 GIHPEGMPGW 3360 CQGFSLDGGS 3370 GVRALKVIQQ 3380 GNRPGLIYNI 3390 GIDVKKGRGR 3400 YIDTCMVIFA 3410 PRYLLDNKSS 3420 HKLAFAQREF 3430 ARGQGTANPE 3440 GYISTLPGSS 3450 VVFHWPRNDY 3460 DQLLCVRLMD 3470 VPNCIWSGGF 3480 EVNKNNSFHI 3490 NMRDTLGKCF 3500 FLRVEITLRG 3510 ATYRISFSDT 3520 DQLPPPFRID 3530 NFSKVPVVFT 3540 QHGVAEPRLR 3550 TEVKPMTSLD 3560 YAWDEPTLPP 3570 FITLTVKGAG 3580 SSEINCNMND 3590 FQDNRQLYYE 3600 NFIYIAATYT 3610 FSGLQEGTGR 3620 PVASNKAITC 3630 AELVLDVSPK 3640 TQRVILKKKE 3650 PGKRSQLWRM 3660 TGTGMLAHEG 3670 SSVPHNPNKP 3680 SAARSTEGSA 3690 ILDIAGLAAV 3700 TDNRYEPLML 3710 RKPDRRRSTT 3720 QTWSFREGKL 3730 TCGLHGLVVQ 3740 AKGGLSGLFD 3750 GAEVVLGPDT 3760 SMELLGPVPP 3770 EQQFINQKMR 3780 PGSGMLSIRV 3790 IPDGPTRALQ 3800 ITDFCHRKSS 3810 RSYEVDELPV 3820 TEQELQKLKN 3830 PDTEQELEVL 3840 VRLEGGIGLS 3850 LINKVPEELV 3860 FASLTGINVH 3870 YTQLATSHML 3880 ELSIQDVQVD 3890 NQLIGTTQPF 3900 MLYVTPLSNE 3910 NEVIETGPAV 3920 QVNAVKFPSK 3930 SALTNIYKHL 3940 MITAQRFTVQ 3950 IEEKLLLKLL 3960 SFFGYDQAES 3970 EVEKYDENLH 3980 EKTAEQGGTP 3990 IRYYFENLKI 4000 SIPQIKLSVF 4010 TSNKLPLDLK 4020 ALKSTLGFPL 4030 IRFEDAVINL 4040 DPFTRVHPYE 4050 TKEFIINDIL 4060 KHFQEELLSQ 4070 AARILGSVDF 4080 LGNPMGLLND 4090 VSEGVTGLIK 4100 YGNVGGLIRN 4110 VTHGVSNSAA 4120 KFAGTLSDGL 4130 GKTMDNRHQS 4140 EREYIRYHAA 4150 TSGEHLVAGI 4160 HGLAHGIIGG 4170 LTSVITSTVE 4180 GVKTEGGVSG 4190 FISGLGKGLV 4200 GTVTKPVAGA 4210 LDFASETAQA 4220 VRDTATLSGP 4230 RTQAQRVRKP 4240 RCCTGPQGLL 4250 PRYSESQAEG 4260 QEQLFKLTDN 4270 IQDEFFIAVE 4280 NIDSYCVLIS 4290 SKAVYFLKSG 4300 DYVDREAIFL 4310 EVKYDDLYHC 4320 LVSKDHGKVY 4330 VQVTKKAVST 4340 SSGVSIPGPS 4350 HQKPMVHVKS 4360 EVLAVKLSQE 4370 INYAKSLYYE 4380 QQLMLRLSEN REQLELDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005739 mitochondrion
Biological Process GO:0006869 lipid transport
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:1901526 positive regulation of mitophagy
Biological Process GO:0045053 protein retention in Golgi apparatus
Biological Process GO:0006623 protein targeting to vacuole

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.