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Overview

Uniprot IDQ5TZA2
Protein NameRootletin
Gene NameCROCC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1246 ANEDKEQKLALLEEA

Function

Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858)

Protein Sequence

10 MSLGLAGAQE 20 VELTLETVIQ 30 TLESSVLCQE 40 KGLGARDLAQ 50 DAQITSLPAL 60 IREIVTRNLS 70 QPESPVLLPA 80 TEMASLLSLQ 90 EENQLLQQEL 100 SRVEDLLAQS 110 RAERDELAIK 120 YNAVSERLEQ 130 ALRLEPGELE 140 TQEPRGLVRQ 150 SVELRRQLQE 160 EQASYRRKLQ 170 AYQEGQQRQA 180 QLVQRLQGKI 190 LQYKKRCSEL 200 EQQLLERSGE 210 LEQQRLRDTE 220 HSQDLESALI 230 RLEEEQQRSA 240 SLAQVNAMLR 250 EQLDQAGSAN 260 QALSEDIRKV 270 TNDWTRCRKE 280 LEHREAAWRR 290 EEESFNAYFS 300 NEHSRLLLLW 310 RQVVGFRRLV 320 SEVKMFTERD 330 LLQLGGELAR 340 TSRAVQEAGL 350 GLSTGLRLAE 360 SRAEAALEKQ 370 ALLQAQLEEQ 380 LRDKVLREKD 390 LAQQQMQSDL 400 DKADLSARVT 410 ELGLAVKRLE 420 KQNLEKDQVN 430 KDLTEKLEAL 440 ESLRLQEQAA 450 LETEDGEGLQ 460 QTLRDLAQAV 470 LSDSESGVQL 480 SGSERTADAS 490 NGSLRGLSGQ 500 RTPSPPRRSS 510 PGRGRSPRRG 520 PSPACSDSST 530 LALIHSALHK 540 RQLQVQDMRG 550 RYEASQDLLG 560 TLRKQLSDSE 570 SERRALEEQL 580 QRLRDKTDGA 590 MQAHEDAQRE 600 VQRLRSANEL 610 LSREKSNLAH 620 SLQVAQQQAE 630 ELRQEREKLQ 640 AAQEELRRQR 650 DRLEEEQEDA 660 VQDGARVRRE 670 LERSHRQLEQ 680 LEGKRSVLAK 690 ELVEVREALS 700 RATLQRDMLQ 710 AEKAEVAEAL 720 TKAEAGRVEL 730 ELSMTKLRAE 740 EASLQDSLSK 750 LSALNESLAQ 760 DKLDLNRLVA 770 QLEEEKSALQ 780 GRQRQAEQEA 790 TVAREEQERL 800 EELRLEQEVA 810 RQGLEGSLRV 820 AEQAQEALEQ 830 QLPTLRHERS 840 QLQEQLAQLS 850 RQLSGREQEL 860 EQARREAQRQ 870 VEALERAARE 880 KEALAKEHAG 890 LAVQLVAAER 900 EGRTLSEEAT 910 RLRLEKEALE 920 GSLFEVQRQL 930 AQLEARREQL 940 EAEGQALLLA 950 KETLTGELAG 960 LRQQIIATQE 970 KASLDKELMA 980 QKLVQAEREA 990 QASLREQRAA 1000 HEEDLQRLQR 1010 EKEAAWRELE 1020 AERAQLQSQL 1030 QREQEELLAR 1040 LEAEKEELSE 1050 EIAALQQERD 1060 EGLLLAESEK 1070 QQALSLKESE 1080 KTALSEKLMG 1090 TRHSLATISL 1100 EMERQKRDAQ 1110 SRQEQDRSTV 1120 NALTSELRDL 1130 RAQREEAAAA 1140 HAQEVRRLQE 1150 QARDLGKQRD 1160 SCLREAEELR 1170 TQLRLLEDAR 1180 DGLRRELLEA 1190 QRKLRESQEG 1200 REVQRQEAGE 1210 LRRSLGEGAK 1220 EREALRRSNE 1230 ELRSAVKKAE 1240 SERISLKLAN 1250 EDKEQKLALL 1260 EEARTAVGKE 1270 AGELRTGLQE 1280 VERSRLEARR 1290 ELQELRRQMK 1300 MLDSENTRLG 1310 RELAELQGRL 1320 ALGERAEKES 1330 RRETLGLRQR 1340 LLKGEASLEV 1350 MRQELQVAQR 1360 KLQEQEGEFR 1370 TRERRLLGSL 1380 EEARGTEKQQ 1390 LDHARGLELK 1400 LEAARAEAAE 1410 LGLRLSAAEG 1420 RAQGLEAELA 1430 RVEVQRRAAE 1440 AQLGGLRSAL 1450 RRGLGLGRAP 1460 SPAPRPVPGS 1470 PARDAPAEGS 1480 GEGLNSPSTL 1490 ECSPGSQPPS 1500 PGPATSPASP 1510 DLDPEAVRGA 1520 LREFLQELRS 1530 AQRERDELRT 1540 QTSALNRQLA 1550 EMEAERDSAT 1560 SRARQLQKAV 1570 AESEEARRSV 1580 DGRLSGVQAE 1590 LALQEESVRR 1600 SERERRATLD 1610 QVATLERSLQ 1620 ATESELRASQ 1630 EKISKMKANE 1640 TKLEGDKRRL 1650 KEVLDASESR 1660 TVKLELQRRS 1670 LEGELQRSRL 1680 GLSDREAQAQ 1690 ALQDRVDSLQ 1700 RQVADSEVKA 1710 GTLQLTVERL 1720 NGALAKVEES 1730 EGALRDKVRG 1740 LTEALAQSSA 1750 SLNSTRDKNL 1760 HLQKALTACE 1770 HDRQVLQERL 1780 DAARQALSEA 1790 RKQSSSLGEQ 1800 VQTLRGEVAD 1810 LELQRVEAEG 1820 QLQQLREVLR 1830 QRQEGEAAAL 1840 NTVQKLQDER 1850 RLLQERLGSL 1860 QRALAQLEAE 1870 KREVERSALR 1880 LEKDRVALRR 1890 TLDKVEREKL 1900 RSHEDTVRLS 1910 AEKGRLDRTL 1920 TGAELELAEA 1930 QRQIQQLEAQ 1940 VVVLEQSHSP 1950 AQLEVDAQQQ 1960 QLELQQEVER 1970 LRSAQAQTER 1980 TLEARERAHR 1990 QRVRGLEEQV 2000 STLKGQLQQE 2010 LRRSSAPFSP PSGPPEK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097729 9+2 motile cilium
Cellular Component GO:0005814 centriole
Cellular Component GO:0005813 centrosome
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0035253 ciliary rootlet
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0120219 subapical part of cell
Molecular Function GO:0003779 actin binding
Molecular Function GO:0019894 kinesin binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030030 cell projection organization
Biological Process GO:0010457 centriole-centriole cohesion
Biological Process GO:0007098 centrosome cycle
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0045724 positive regulation of cilium assembly
Biological Process GO:1903566 positive regulation of protein localization to cilium

Reference

PMID: N/A