Search Results
Overview
| Uniprot ID | Q5TZP7 |
|---|---|
| Protein Name | DNA repair nuclease/redox regulator APEX1 |
| Gene Name | APEX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | ETKCSENKLPAELQE |
| 203 | LKGLASRKPLVLCGD |
| 299 | LPALCDSKIRSKALG |
Function
Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends
Protein Sequence
10
MPKRGKKGAV
20
AEDGDELRTE
30
PEAKKSKTAA
40
KKNDKEAAGE
50
GPALYEDPPD
60
QKTSPSGKPA
70
TLKICSWNVD
80
GLRAWIKKKG
90
LDWVKEEAPD
100
ILCLQETKCS
110
ENKLPAELQE
120
LPGLSHQYWS
130
APSDKEGYSG
140
VGLLSRQCPL
150
KVSYGIGDEE
160
HDQEGRVIVA
170
EFDSFVLVTA
180
YVPNAGRGLV
190
RLEYRQRWDE
200
AFRKFLKGLA
210
SRKPLVLCGD
220
LNVAHEEIDL
230
RNPKGNKKNA
240
GFTPQERQGF
250
GELLQAVPLA
260
DSFRHLYPNT
270
PYAYTFWTYM
280
MNARSKNVGW
290
RLDYFLLSHS
300
LLPALCDSKI
310
RSKALGSDHC
PITLYLAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0008311 | double-stranded DNA 3'-5' DNA exonuclease activity |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0004519 | endonuclease activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
Reference
PMID: N/A