Search Results

Overview

Uniprot IDQ5U1X1
Protein NameOligoribonuclease, mitochondrial
Gene NameRexo2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
103 WCKEHHGKSGLTKAV
173 IIDVSTVKELCRRWY
225 KTDEKKRKIIENGEN

Function

3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (By similarity). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (By similarity). Essential for embryonic development (By similarity)

Protein Sequence

10 MLGVSLGARL 20 LRGVGGRRGQ 30 FGARGVSEGS 40 AAMAAGESMA 50 QRMVWVDLEM 60 TGLDIEKDQI 70 IEMACLITDS 80 DLNILAEGPN 90 LIIKQPDELL 100 DSMSDWCKEH 110 HGKSGLTKAV 120 KESTVTLQQA 130 EYEFLSFVRQ 140 QTPPGLCPLA 150 GNSVHADKKF 160 LDKHMPQFMK 170 HLHYRIIDVS 180 TVKELCRRWY 190 PEDYEFAPKK 200 AASHRALDDI 210 SESIKELQFY 220 RNNIFKKKTD 230 EKKRKIIENG ENEKPVS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008408 3'-5' exonuclease activity
Molecular Function GO:0008296 3'-5'-DNA exonuclease activity
Molecular Function GO:0000175 3'-5'-RNA exonuclease activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0003676 nucleic acid binding
Biological Process GO:2000827 mitochondrial RNA surveillance
Biological Process GO:0006139 nucleobase-containing compound metabolic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.