Search Results

Overview

Uniprot ID	Q5U1Z0
Protein Name	Rab3 GTPase-activating protein non-catalytic subunit
Gene Name	Rab3gap2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
911	RASPPAAKASSPQTE

Function

Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. The complex has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and has guanine nucleotide exchange factor (GEF) activity towards RAB18. The Rab3GAP complex acts as a GEF for RAB18 by promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)

Protein Sequence

10 MACSIVQFCS 20 FQDLQSARDF 30 LFPQLREETP 40 GALRRDPSKT 50 SNWEDDSWGA 60 WEETEPQEPE 70 EEGNTSKTQK 80 HSWLQECVLS 90 LSPTSDLMVI 100 AREQKAAFLV 110 RKWKHSDKGK 120 EEMQFAVGWS 130 GSVSAEEGEY 140 VTSALCIPLA 150 SQKRSSTGRP 160 DWTCIVVGFT 170 SGYVRFYTEG 180 VLLLAQLLNE 190 DRVLQLKCRT 200 YEIPRHPGVT 210 EQNEELSILY 220 PAAIVTIDGF 230 SLFQSLRACR 240 NQVAKAAASG 250 NENIQPPPLA 260 YKKWGLQDID 270 TIIDHASIGI 280 MTLSPFDQMK 290 TASNIGGFNA 300 AIKNSPPAMS 310 QYITVGSSPF 320 TGFFYALEGS 330 TQPLLSHVAL 340 AVASKLTSAL 350 FSAASGWLGW 360 KSKHEEETVQ 370 KQKPKMEPAT 380 PLAVRFGLPD 390 SRRHGESICL 400 SPCNTLAAVT 410 DDFGRVILLD 420 VARGIAIRMW 430 KGYRDAQIGW 440 IQIVEDLHER 450 VPEKGDFSPF 460 GNTQGPSRVA 470 QFLVIYAPRR 480 GILEVWSTQQ 490 GPRVGAFNVG 500 KHCRLLYPGY 510 KIMGLNNVTS 520 QSWQPQTYQI 530 CLVDPVSASV 540 KAVNVPFHLA 550 LSDKKSERAK 560 DLHLVKKLAA 570 LLRAKSPRPD 580 SFEAEIKELI 590 LDIKYPATKK 600 QALESILASD 610 RVSFSCLRNV 620 TQTSMDTLKN 630 QELESVDEGL 640 LQFCASKLKL 650 LHLYESVSQL 660 NTLDFHSDTP 670 FSDNDLAVLL 680 RLDDKELLKL 690 RALLEKYKQE 700 NTKATVRFSE 710 DADGVLPVKT 720 FLEYLDYEKD 730 ALSIRKTSEE 740 ECVALGSFFF 750 WKCLHGESST 760 EDMCHTLESA 770 GLSPQQLLSL 780 LLSVWLSKEK 790 DILDKPQSVC 800 CLHTMLSLLS 810 KMKVAIDETW 820 DSQSVSPWWQ 830 QMRMACIQSE 840 NNGAALLSAH 850 VGHSVAAQMS 860 SSATDKKFSQ 870 MVLDADAEAL 880 TDSWEALSLD 890 TEYWKLLLRQ 900 LEDCLILQTL 910 LHSRASPPAA 920 KASSPQTEPL 930 PRLSVKKLLE 940 GGKGGIADSV 950 AKWIFKQDLS 960 PELLKCANRE 970 KDVENPDEPR 980 EGIARSPPEV 990 SEVETDLGAV 1000 PDLLRLAYEQ 1010 FPCSLELDVL 1020 HAHCCWEYVV 1030 QWNKDPEEAR 1040 FLVRSIEHLR 1050 HILNPHVQNG 1060 ISLMMWNTFL 1070 VKRFSAATYL 1080 MDKVGKSPKD 1090 RLCRRDVGMS 1100 DTALTSFLGS 1110 CLDLLQTSLE 1120 ADISRDEVQV 1130 PVLDTEDAWL 1140 SVEGPTSIVE 1150 LALEQKPIHY 1160 PLVEHHSILC 1170 SILYAAMSFS 1180 LKSVKPLALF 1190 DSKGKNAFFK 1200 DLTSIQLLPS 1210 GEMDPNFISV 1220 RQQFLLKVVS 1230 AAVQAQHSKD 1240 KDPSARAADT 1250 HGQDLNWTAL 1260 AVDLAHHLQV 1270 SEDVIRRHYV 1280 GELYSYGADL 1290 LGEEAILQVQ 1300 DKEVLASQLL 1310 VLTGQRLAHA 1320 LFHTQTKEGM 1330 ELLARLPPTL 1340 CTWLKAMNPQ 1350 DLQNTGVPVA 1360 ATAKLVHKVM 1370 ELLPEKHGQY 1380 SLALHLIEAV EAMATL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005776	autophagosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0042734	presynaptic membrane
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0030234	enzyme regulator activity
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0097051	establishment of protein localization to endoplasmic reticulum membrane
Biological Process	GO:0016236	macroautophagy
Biological Process	GO:2000786	positive regulation of autophagosome assembly
Biological Process	GO:1903373	positive regulation of endoplasmic reticulum tubular network organization
Biological Process	GO:1903061	positive regulation of protein lipidation
Biological Process	GO:0043087	regulation of GTPase activity
Biological Process	GO:0099536	synaptic signaling

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.