Search Results
Overview
| Uniprot ID | Q5U2X0 |
|---|---|
| Protein Name | CDKN2A-interacting protein |
| Gene Name | Cdkn2aip |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | EGVEEPSKKRSIEGK |
| 142 | KKRSIEGKNNSSVER |
| 243 | SFVSSLLKSSLNSHV |
Function
Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence
Protein Sequence
10
MAQEVSEYLS
20
QNPRVAAWVE
30
TLRCEGETDK
40
HWRHRREFLL
50
RNAGDLVPAT
60
EETADAESGA
70
RSRQLQQLVS
80
FSMAWANHVF
90
LGCRYPQKVM
100
DKILSMAEGI
110
KVTDAPIHTT
120
RDELVAKVKK
130
RGISSSNEGV
140
EEPSKKRSIE
150
GKNNSSVERD
160
HGKKSAKTDR
170
SAQQENSSGS
180
KGSSTKSESS
190
GTSARSNSGV
200
SHQNSSTSEG
210
DRSVCSQSSS
220
NSSQVTSAGS
230
GKASEPEAPD
240
KHGSASFVSS
250
LLKSSLNSHV
260
TKSTDSRQHS
270
GSPRKNALEG
280
SSVSVSQSSS
290
EIEVPLLGSS
300
GSSEVELPLL
310
SCKSSSETAS
320
SGLTTKASSE
330
ANISSSVSKN
340
SSSSGTSLLM
350
PKSSSTNTSL
360
LTSQVAASLL
370
ASKSSSQSSG
380
SVASKSTSLG
390
SMSQLASKSS
400
SQSSTSQLPS
410
KSTSQSSESS
420
VKFTCRKLTN
430
EDIKQKQPFF
440
NRLYKTVAWK
450
LVAVGGFSPN
460
VNHGELLNAA
470
IEALKATLDV
480
FFVPLKELAD
490
LPQNKSSQES
500
IVCELRCKSV
510
YLGTGCGKSK
520
ENAKAVASRE
530
ALKLFLKKKV
540
VVKICKRKYR
550
GNEIEDLVLL
560
DEESRPVNLP
570
PALKHPQELL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001652 | granular component |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0009967 | positive regulation of signal transduction |
| Biological Process | GO:0031647 | regulation of protein stability |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.