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Overview

Uniprot IDQ5U2Y1
Protein NameGeneral transcription factor II-I
Gene NameGtf2i
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
334 VREFNFEKWNARITD

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity)

Protein Sequence

10 MAQVAMSALP 20 AEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKCTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVAV 160 QGLPEGVAFK 170 HPEHYDLATL 180 KWILENKAGI 190 SFIIKRPFLE 200 PKKHLGGRVM 210 AADADRPMLS 220 PGGSCGPIKV 230 KTEPTEDSGI 240 SLEMAAVTVK 250 EESEDPDYYQ 260 YNIQGSHHSS 270 EGNEGAEVEV 280 PAEDSTQHVP 290 SETSEDPEVE 300 VTIEDDDYSP 310 PTKRPKSSEP 320 PPPPPVPEPT 330 NAGKRKVREF 340 NFEKWNARIT 350 DLRKQVEELF 360 ERKYAQAIKA 370 KGPVTIPYPL 380 FQSHVEDLYV 390 EGLPEGIPFR 400 RPSTYGIPRL 410 ERILLAKERI 420 RFVIKKHELL 430 NSTREDLQLD 440 KPASGVKEEW 450 YARITKLRKM 460 VDQLFCKKFA 470 EALGSTEAKA 480 VPYQKFEAYP 490 NDLYVEGLPE 500 NIPFRSPSWY 510 GIPRLEKIIQ 520 VGNRIKFVIK 530 RPELLTHSTT 540 EVTQPRTNTP 550 VKEDWNVRIT 560 KLRKQVEEIF 570 NLKFAQALGL 580 TEAVKVPYPV 590 FESNPEFLYV 600 EGLPEGIPFR 610 SPTWFGIPRL 620 ERIVRGSNKI 630 KFVVKKPELV 640 VSYLPPGMAS 650 KINTKALQSP 660 KRPRSPGSNS 670 KVPEIEVTVE 680 GPNNNSPQTS 690 TVRTPTQTNG 700 SNVPFKPRGR 710 EFSFEAWNAK 720 ITDLKQKVEN 730 LFNEKCGEAL 740 GLKQAVKVPF 750 ALFESFPEDF 760 YVEGLPEGVP 770 FRRPSTFGIP 780 RLEKILRNKA 790 KIKFIIKKPE 800 MFETAIKEST 810 SSKSPPRKTN 820 SSPSVNTTAS 830 GVEDLNIIQV 840 TIPDDDNERL 850 SKVEKARQLR 860 EQVNDLFSRK 870 FGEAIGMGFP 880 VKVPYRKITI 890 NPGCVVVDGM 900 PPGVSFKAPS 910 YLEISSMRRI 920 LDSAEFIKFT 930 VIRPFPGLVI 940 NNQLVDQNES 950 EGPVIQESAE 960 ASQLEVPATE 970 EIKETDGSSQ IKQEPDPTW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042995 cell projection
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0051019 mitogen-activated protein kinase binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0014886 transition between slow and fast fiber

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.