Search Results

Overview

Uniprot IDQ5U2Y6
Protein NameTuftelin-interacting protein 11
Gene NameTfip11
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
120 DLGPKKLKTGGNFKP
159 IGQKLLQKMGYVPGR
182 IINPIEAKQRKGKGA
187 EAKQRKGKGAVGAYG
241 KKPKYSYKTVEELKA
255 AKGRVSKKLTAPQKE

Function

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity)

Protein Sequence

10 MSLSHLYRDG 20 EGHLDDDDDE 30 RENFEITDWD 40 LQNEFNPNRQ 50 RHWQTKEEAT 60 YGVWAERDSD 70 EERPSFGGKR 80 ARDYSAPVNF 90 ISAGLKKGAA 100 EEADSEDSDA 110 EEKPVKQEDF 120 PKDLGPKKLK 130 TGGNFKPSQK 140 GFAGGTKSFM 150 DFGSWERHTK 160 GIGQKLLQKM 170 GYVPGRGLGK 180 NAQGIINPIE 190 AKQRKGKGAV 200 GAYGSERTTQ 210 SLQDFPVADS 220 EEEAEEEFQK 230 ELSQWRKDPS 240 GSKKKPKYSY 250 KTVEELKAKG 260 RVSKKLTAPQ 270 KELSQVKVID 280 MTGREQKVYY 290 SYSQISHKHS 300 VPDEGVPLLA 310 QLPPTAGKEA 320 KVPGFALPEL 330 EHNLQLLIER 340 TEQEIIQSDR 350 QLQYERDMVV 360 SLSHELEKTA 370 EVLAHEERVI 380 SNLSKVLALV 390 EECEHRMQPH 400 GADPLTLDEC 410 ARIFETLQDK 420 YYEEYRLADR 430 ADLAVAIVYP 440 LVKDYFKDWH 450 PLEDSNYGTQ 460 IISKWKSLLE 470 NDQLLSHSSQ 480 DLSSDAFHRL 490 MWEVWMPFVR 500 NVVAQWQPRN 510 CEPMVDFLDS 520 WAHIIPVWIL 530 DNILDQLIFP 540 KLQKEVDNWN 550 PLTDTVPIHS 560 WIHPWLPLMQ 570 ARLEPLYSPV 580 RSKLSSALQK 590 WHPSDASAKL 600 ILQPWKEVLT 610 PGSWEAFMLR 620 NIVPKLGMCL 630 GELVINPHQQ 640 HMDAFYWVMD 650 WEGMISVSSL 660 VGLLEKHFFP 670 KWLQVLCSWL 680 SNSPNYEEIT 690 KWYLGWKSMF 700 SDQVLAHPSV 710 KDKFNEALDI 720 MNRAVSSNVG 730 AYMQPGAREN 740 IAYLTHTERR 750 KDFQYEAMQE 760 RREAENMAQR 770 GIGVAASSVP 780 MNFKDLIETK 790 AEEHNIVFMP 800 VIGKRHEGKQ 810 LYTFGRIVIY 820 IDRGVVFVQG 830 EKTWVPTSLQ SLIDMAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005681 spliceosomal complex
Cellular Component GO:0071008 U2-type post-mRNA release spliceosomal complex
Molecular Function GO:0003676 nucleic acid binding
Biological Process GO:0031214 biomineral tissue development
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:0000390 spliceosomal complex disassembly

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.