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Overview

Uniprot ID	Q5U312
Protein Name	Ankycorbin
Gene Name	Rai14
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
10	SLKAKFRKSDTNEWN
843	IQTLLKSKEQEVTEL
865	QEELAGLKRCSETSS

Function

Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier

Protein Sequence

10 MKSLKAKFRK 20 SDTNEWNKND 30 DRLLQAVENG 40 DAEKVASLLG 50 KKGASATKHD 60 SEGKTAFHLA 70 AAKGHVECLK 80 VMVTHGVDVT 90 AQDSSGHSAL 100 HIAAKNGHPE 110 YIKKLLQYKS 120 PAESVDNLGK 130 TALHYAAAQG 140 SLQAVQVLCE 150 HKSPINLKDL 160 DGNIPLLVAI 170 QNGHSEACHF 180 LLDHGADVNS 190 RDKNGRTALM 200 LACETGSANT 210 VEALIKKGAD 220 LNLVDSLGHN 230 ALYYSKLSEN 240 AGIQSLLLSK 250 ISQDADLKTP 260 TKAKQHDQVS 270 KISSERSGTP 280 KKRKAPPPPI 290 SPTQLSDVSS 300 PRSITSTPLS 310 GKESVFFAEA 320 PFKAEISSIQ 330 ENKDRLSDST 340 AGADSLLDVS 350 SEADQQDLLV 360 LLQAKVASLT 370 LHNKELQDKL 380 QAKSPKETEA 390 DLSFQSFHST 400 QTDLAPSPSK 410 SSDIPSSDAK 420 SSPPVEHPAG 430 TSTADRDVII 440 QQLQDTLHDL 450 QKRLETSEAE 460 KKQLQDELQS 470 QRTDTTCLNN 480 TEISENGSDL 490 SQKLKDTQSK 500 YEEAMKEVLS 510 VQKQMKLGLL 520 SHESADGDSR 530 LREVRVTDED 540 VDALKQDLQR 550 ALEESKRDKA 560 RVQELETKLV 570 EKEKAEATKP 580 SSEVCEEMRN 590 SYCSVIENMN 600 KEKAFLFEKY 610 QQAQEEIMKL 620 KDTLKSQMPQ 630 EAPDDSGDMK 640 ETMNRMVDEL 650 NKQVSELSQL 660 YREAQAELED 670 YRKRKSLEDA 680 TEYIHRAEHE 690 RLMHLSNLSR 700 TKAEESLSDM 710 RSQYSKVLNE 720 LTQLKQLVDA 730 HKENSVSITE 740 HLEVITTLRT 750 MAKEMEEKTV 760 TLQEHLASKE 770 GEVAKLEKQL 780 AEEKAAMSDA 790 MVPKASYEKL 800 QASLESEVNA 810 LAAKLKESVK 820 EKEKAHSEVA 830 QVRSEVSQAK 840 REKENIQTLL 850 KSKEQEVTEL 860 VQKFQRAQEE 870 LAGLKRCSET 880 SSKLEEDKDE 890 KINEMTKEVL 900 KLKEALNSLS 910 QLSYSTSSSK 920 RQTQQLEMLQ 930 QQVKQLQNQL 940 AECKKQHQEV 950 VSVYRMHLLY 960 AVQGQMDEDV 970 QKVLKQILTM CKNQSQKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0001725	stress fiber
Molecular Function	GO:0003779	actin binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007283	spermatogenesis

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.