Overview
| Uniprot ID | Q5U316 |
|---|
| Protein Name | Ras-related protein Rab-35 |
|---|
| Gene Name | Rab35 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 58 |
EINGEKVKLQIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity)
Protein Sequence
10
MARDYDHLFK
20
LLIIGDSGVG
30
KSSLLLRFAD
40
NTFSGSYITT
50
IGVDFKIRTV
60
EINGEKVKLQ
70
IWDTAGQERF
80
RTITSTYYRG
90
THGVIVVYDV
100
TSAESFVNVK
110
RWLHEINQNC
120
DDVCRILVGN
130
KNDDPERKVV
140
ETEDAYKFAG
150
QMGIQLFETS
160
AKENVNVEEM
170
FNCITELVLR
180
AKKDNLAKQQ
190
QQQQNDVVKL
200
TKNSKRKKRC
C
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031253 |
cell projection membrane |
| Cellular Component |
GO:0045334 |
clathrin-coated endocytic vesicle |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0045171 |
intercellular bridge |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
| Biological Process |
GO:0019882 |
antigen processing and presentation |
| Biological Process |
GO:1990090 |
cellular response to nerve growth factor stimulus |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0016197 |
endosomal transport |
| Biological Process |
GO:0008104 |
intracellular protein localization |
| Biological Process |
GO:0000281 |
mitotic cytokinesis |
| Biological Process |
GO:0031175 |
neuron projection development |
| Biological Process |
GO:0048227 |
plasma membrane to endosome transport |
| Biological Process |
GO:0036010 |
protein localization to endosome |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0032482 |
Rab protein signal transduction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.