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Overview

Uniprot ID	Q5U318
Protein Name	Astrocytic phosphoprotein PEA-15
Gene Name	Pea15
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
109	IPSAKKYKDIIRQPS
128	IKLAPPPKKA*****
28	EQLKSACKEDIPSEK
88	DYRTRVLKISEEDEL
98	EEDELDTKLTRIPSA

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity)

Protein Sequence

10 MAEYGTLLQD 20 LTNNITLEDL 30 EQLKSACKED 40 IPSEKSEEIT 50 TGSAWFSFLE 60 SHNKLDKDNL 70 SYIEHIFEIS 80 RRPDLLTMVV 90 DYRTRVLKIS 100 EEDELDTKLT 110 RIPSAKKYKD 120 IIRQPSEEEI 130 IKLAPPPKKA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0046325	negative regulation of D-glucose import across plasma membrane
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.