Search Results
Overview
| Uniprot ID | Q5U3Z7 |
|---|---|
| Protein Name | Serine hydroxymethyltransferase |
| Gene Name | Shmt2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 302 | GVRTVDPKTGQEIPY |
| 464 | EVKRKTAKLQDFKSF |
| 474 | DFKSFLLKDPETSQR |
Function
Interconversion of serine and glycine
Protein Sequence
10
MVPFSLLRTT
20
RPLQRCGQLV
30
CMAARAQHSE
40
VAQKQAGEAA
50
GGWTGQESLS
60
DSDPEIWELL
70
QREKDRQCRG
80
LELIASENFC
90
SRAALEALGS
100
CLNNKYSEGY
110
PGKRYYGGAE
120
VVDEIELLCQ
130
RRALEAFDLD
140
PAQWGVNVQP
150
YSGSPANLAA
160
YTALLQPHDR
170
IMGLDLPDGG
180
HLTHGYMSDV
190
KRISATSIFF
200
ESMPYKLNPQ
210
TGLIDYDQLA
220
LTARLFRPRL
230
IIAGTSAYAR
240
LIDYARMREV
250
CDEVKAHLLA
260
DMAHISGLVA
270
AKVIPSPFKY
280
ADIVTTTTHK
290
TLRGARSGLI
300
FYRKGVRTVD
310
PKTGQEIPYT
320
FEDRINFAVF
330
PSLQGGPHNH
340
AIAAVAVALK
350
QACTPMFREY
360
SLQVLRNAQA
370
MADALLKRGY
380
SLVSGGTDTH
390
LVLVDLRPKG
400
LDGARAERVL
410
ELVSITANKN
420
TCPGDRSAIT
430
PGGLRLGAPA
440
LTSRQFREDD
450
FRRVVDFIDE
460
GVNIGLEVKR
470
KTAKLQDFKS
480
FLLKDPETSQ
490
RLANLRQQVE
500
QFARGFPMPG
FDER
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070552 | BRISC complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0016597 | amino acid binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0004372 | glycine hydroxymethyltransferase activity |
| Molecular Function | GO:0120567 | hydroxytrimethyllysine aldolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008732 | L-allo-threonine aldolase activity |
| Molecular Function | GO:0008168 | methyltransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0015943 | formate biosynthetic process |
| Biological Process | GO:0006545 | glycine biosynthetic process |
| Biological Process | GO:0019264 | glycine biosynthetic process from L-serine |
| Biological Process | GO:0006544 | glycine metabolic process |
| Biological Process | GO:0006564 | L-serine biosynthetic process |
| Biological Process | GO:0006563 | L-serine metabolic process |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0006730 | one-carbon metabolic process |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0070536 | protein K63-linked deubiquitination |
| Biological Process | GO:0051262 | protein tetramerization |
| Biological Process | GO:1903715 | regulation of aerobic respiration |
| Biological Process | GO:0070129 | regulation of mitochondrial translation |
| Biological Process | GO:0002082 | regulation of oxidative phosphorylation |
| Biological Process | GO:0034340 | response to type I interferon |
| Biological Process | GO:0035999 | tetrahydrofolate interconversion |
| Biological Process | GO:0046653 | tetrahydrofolate metabolic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.