Search Results

Overview

Uniprot IDQ5UIP0
Protein NameTelomere-associated protein RIF1
Gene NameRIF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1014 DSFLAQTKNKKENMK
1016 FLAQTKNKKENMKPA
1027 MKPAAKLKLESSSLK
1036 ESSSLKVKGEILLEE
1274 QREGTFSKSDSEKIV
1279 FSKSDSEKIVNGTKR
1440 DKENSHQKKERRKEE
1441 KENSHQKKERRKEEE
1467 DDVLPKQKLIAEQTL
1575 RSGKWKNKSNESVDI
1721 QTLECQHKRSRRVRR
1913 VTESNLEKAKTMELN
1915 ESNLEKAKTMELNVG
2183 SPSTSILKRGLKRSQ
2200 EISSPVNKVRRVSFA
2238 SNSSPIGKSVKTSPT
2249 TSPTTQSKHNTTSAK
2256 KHNTTSAKGFLSPGS
791 QRPSDWSKKKNEPLG

Function

Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity)

Protein Sequence

10 MTARGQSPLA 20 PLLETLEDPS 30 ASHGGQTDAY 40 LTLTSRMTGE 50 EGKEVITEIE 60 KKLPRLYKVL 70 KTHISSQNSE 80 LSSAALQALG 90 FCLYNPKITS 100 ELSEANALEL 110 LSKLNDTIKN 120 SDKNVRTRAL 130 WVISKQTFPS 140 EVVGKMVSSI 150 IDSLEILFNK 160 GETHSAVVDF 170 EALNVIVRLI 180 EQAPIQMGEE 190 AVRWAKLVIP 200 LVVHSAQKVH 210 LRGATALEMG 220 MPLLLQKQQE 230 IASITEQLMT 240 TKLISELQKL 250 FMSKNETYVL 260 KLWPLFVKLL 270 GRTLHRSGSF 280 INSLLQLEEL 290 GFRSGAPMIK 300 KIAFIAWKSL 310 IDNFALNPDI 320 LCSAKRLKLL 330 MQPLSSIHVR 340 TETLALTKLE 350 VWWYLLMRLG 360 PHLPANFEQV 370 CVPLIQSTIS 380 IDSNASPQGN 390 SCHVATSPGL 400 NPMTPVHKGA 410 SSPYGAPGTP 420 RMNLSSNLGG 430 MATIPSIQLL 440 GLEMLLHFLL 450 GPEALSFAKQ 460 NKLVLSLEPL 470 EHPLISSPSF 480 FSKHANTLIT 490 AVHDSFVAVG 500 KDAPDVVVSA 510 IWKELISLVK 520 SVTESGNKKE 530 KPGSEVLTLL 540 LKSLESIVKS 550 EVFPVSKTLV 560 LMEITIKGLP 570 QKVLGSPAYQ 580 VANMDILNGT 590 PALFLIQLIF 600 NNFLECGVSD 610 ERFFLSLESL 620 VGCVLSGPTS 630 PLAFSDSVLN 640 VINQNAKQLE 650 NKEHLWKMWS 660 VIVTPLTELI 670 NQTNEVNQGD 680 ALEHNFSAIY 690 GALTLPVNHI 700 FSEQRFPVAT 710 MKTLLRTWSE 720 LYRAFARCAA 730 LVATAEENLC 740 CEELSSKIMS 750 SLEDEGFSNL 760 LFVDRIIYII 770 TVMVDCIDFS 780 PYNIKYQPKV 790 KSPQRPSDWS 800 KKKNEPLGKL 810 TSLFKLIVKV 820 IYSFHTLSFK 830 EAHSDTLFTI 840 GNSITGIISS 850 VLGHISLPSM 860 IRKIFATLTR 870 PLALFYENSK 880 LDEVPKVYSC 890 LNNKLEKLLG 900 EIIACLQFSY 910 TGTYDSELLE 920 QLSPLLCIIF 930 LHKNKQIRKQ 940 SAQFWNATFA 950 KVMMLVYPEE 960 LKPVLTQAKQ 970 KFLLLLPGLE 980 TVEMMEESSG 990 PYSDGTENSQ 1000 LNVKISGMER 1010 KSNGKRDSFL 1020 AQTKNKKENM 1030 KPAAKLKLES 1040 SSLKVKGEIL 1050 LEEEKSTDFV 1060 FIPPEGKDAK 1070 ERILTDHQKE 1080 VLKTKRCDIP 1090 AMYNNLDVSQ 1100 DTLFTQYSQE 1110 EPMEIPTLTR 1120 KPKEDSKMMI 1130 TEEQMDSDIV 1140 IPQDVTEDCG 1150 MAEHLEKSSL 1160 SNNECGSLDK 1170 TSPEMSNSNN 1180 DERKKALISS 1190 RKTSTECASS 1200 TENSFVVSSS 1210 SVSNTTVAGT 1220 PPYPTSRRQT 1230 FITLEKFDGS 1240 ENRPFSPSPL 1250 NNISSTVTVK 1260 NNQETMIKTD 1270 FLPKAKQREG 1280 TFSKSDSEKI 1290 VNGTKRSSRR 1300 AGKAEQTGNK 1310 RSKPLMRSEP 1320 EKNTEESVEG 1330 IVVLENNPPG 1340 LLNQTECVSD 1350 NQVHLSESTM 1360 EHDNTKLKAA 1370 TVENAVLLET 1380 NTVEEKNVEI 1390 NLESKENTPP 1400 VVISADQMVN 1410 EDSQVQITPN 1420 QKTLRRSSRR 1430 RSEVVESTTE 1440 SQDKENSHQK 1450 KERRKEEEKP 1460 LQKSPLHIKD 1470 DVLPKQKLIA 1480 EQTLQENLIE 1490 KGSNLHEKTL 1500 GETSANAETE 1510 QNKKKADPEN 1520 IKSEGDGTQD 1530 IVDKSSEKLV 1540 RGRTRYQTRR 1550 ASQGLLSSIE 1560 NSESDSSEAK 1570 EEGSRKKRSG 1580 KWKNKSNESV 1590 DIQDQEEKVV 1600 KQECIKAENQ 1610 SHDYKATSEE 1620 DVSIKSPICE 1630 KQDESNTVIC 1640 QDSTVTSDLL 1650 QVPDDLPNVC 1660 EEKNETSKYA 1670 EYSFTSLPVP 1680 ESNLRTRNAI 1690 KRLHKRDSFD 1700 NCSLGESSKI 1710 GISDISSLSE 1720 KTFQTLECQH 1730 KRSRRVRRSK 1740 GCDCCGEKSQ 1750 PQEKSLIGLK 1760 NTENNDVEIS 1770 ETKKADVQAP 1780 VSPSETSQAN 1790 PYSEGQFLDE 1800 HHSVNFHLGL 1810 KEDNDTINDS 1820 LIVSETKSKE 1830 NTMQESLPSG 1840 IVNFREEICD 1850 MDSSEAMSLE 1860 SQESPNENFK 1870 TVGPCLGDSK 1880 NVSQESLETK 1890 EEKPEETPKM 1900 ELSLENVTVE 1910 GNACKVTESN 1920 LEKAKTMELN 1930 VGNEASFHGQ 1940 ERTKTGISEE 1950 AAIEENKRND 1960 DSEADTAKLN 1970 AKEVATEEFN 1980 SDISLSDNTT 1990 PVKLNAQTEI 2000 SEQTAAGELD 2010 GGNDVSDLHS 2020 SEETNTKMKN 2030 NEEMMIGEAM 2040 AETGHDGETE 2050 NEGITTKTSK 2060 PDEAETNMLT 2070 AEMDNFVCDT 2080 VEMSTEEGII 2090 DANKTETNTE 2100 YSKSEEKLDN 2110 NQMVMESDIL 2120 QEDHHTSQKV 2130 EEPSQCLASG 2140 TAISELIIED 2150 NNASPQKLRE 2160 LDPSLVSAND 2170 SPSGMQTRCV 2180 WSPLASPSTS 2190 ILKRGLKRSQ 2200 EDEISSPVNK 2210 VRRVSFADPI 2220 YQAGLADDID 2230 RRCSIVRSHS 2240 SNSSPIGKSV 2250 KTSPTTQSKH 2260 NTTSAKGFLS 2270 PGSRSPKFKS 2280 SKKCLISEMA 2290 KESIPCPTES 2300 VYPPLVNCVA 2310 PVDIILPQIT 2320 SNMWARGLGQ 2330 LIRAKNIKTI 2340 GDLSTLTASE 2350 IKTLPIRSPK 2360 VSNVKKALRI 2370 YHEQQVKTRG 2380 LEEIPVFDIS 2390 EKTVNGIENK 2400 SLSPDEERLV 2410 SDIIDPVALE 2420 IPLSKNLLAQ 2430 ISALALQLDS 2440 EDLHNYSGSQ 2450 LFEMHEKLSC 2460 MANSVIKNLQ 2470 SRWRSPSHEN SI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0140445 chromosome, telomeric repeat region
Cellular Component GO:0000793 condensed chromosome
Cellular Component GO:0001939 female pronucleus
Cellular Component GO:0001940 male pronucleus
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035861 site of double-strand break
Cellular Component GO:0051233 spindle midzone
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair
Biological Process GO:2000042 negative regulation of double-strand break repair via homologous recombination
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0045830 positive regulation of isotype switching
Biological Process GO:0031509 subtelomeric heterochromatin formation
Biological Process GO:0000723 telomere maintenance
Biological Process GO:0043247 telomere maintenance in response to DNA damage

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.