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Overview

Uniprot IDQ5VSL9
Protein NameStriatin-interacting protein 1
Gene NameSTRIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
47 AGLLPGGKAREFNRN

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation

Protein Sequence

10 MEPAVGGPGP 20 LIVNNKQPQP 30 PPPPPPAAAQ 40 PPPGAPRAAA 50 GLLPGGKARE 60 FNRNQRKDSE 70 GYSESPDLEF 80 EYADTDKWAA 90 ELSELYSYTE 100 GPEFLMNRKC 110 FEEDFRIHVT 120 DKKWTELDTN 130 QHRTHAMRLL 140 DGLEVTAREK 150 RLKVARAILY 160 VAQGTFGECS 170 SEAEVQSWMR 180 YNIFLLLEVG 190 TFNALVELLN 200 MEIDNSAACS 210 SAVRKPAISL 220 ADSTDLRVLL 230 NIMYLIVETV 240 HQECEGDKAE 250 WRTMRQTFRA 260 ELGSPLYNNE 270 PFAIMLFGMV 280 TKFCSGHAPH 290 FPMKKVLLLL 300 WKTVLCTLGG 310 FEELQSMKAE 320 KRSILGLPPL 330 PEDSIKVIRN 340 MRAASPPASA 350 SDLIEQQQKR 360 GRREHKALIK 370 QDNLDAFNER 380 DPYKADDSRE 390 EEEENDDDNS 400 LEGETFPLER 410 DEVMPPPLQH 420 PQTDRLTCPK 430 GLPWAPKVRE 440 KDIEMFLESS 450 RSKFIGYTLG 460 SDTNTVVGLP 470 RPIHESIKTL 480 KQHKYTSIAE 490 VQAQMEEEYL 500 RSPLSGGEEE 510 VEQVPAETLY 520 QGLLPSLPQY 530 MIALLKILLA 540 AAPTSKAKTD 550 SINILADVLP 560 EEMPTTVLQS 570 MKLGVDVNRH 580 KEVIVKAISA 590 VLLLLLKHFK 600 LNHVYQFEYM 610 AQHLVFANCI 620 PLILKFFNQN 630 IMSYITAKNS 640 ISVLDYPHCV 650 VHELPELTAE 660 SLEAGDSNQF 670 CWRNLFSCIN 680 LLRILNKLTK 690 WKHSRTMMLV 700 VFKSAPILKR 710 ALKVKQAMMQ 720 LYVLKLLKVQ 730 TKYLGRQWRK 740 SNMKTMSAIY 750 QKVRHRLNDD 760 WAYGNDLDAR 770 PWDFQAEECA 780 LRANIERFNA 790 RRYDRAHSNP 800 DFLPVDNCLQ 810 SVLGQRVDLP 820 EDFQMNYDLW 830 LEREVFSKPI SWEELLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0090443 FAR/SIN/STRIPAK complex
Cellular Component GO:0005634 nucleus
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0035331 negative regulation of hippo signaling
Biological Process GO:0035330 regulation of hippo signaling

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.