Search Results

Overview

Uniprot ID	Q5VT25
Protein Name	Serine/threonine-protein kinase MRCK alpha
Gene Name	CDC42BPA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1541	MVRNINNKRRYSFRV

Function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624)

Protein Sequence

10 MSGEVRLRQL 20 EQFILDGPAQ 30 TNGQCFSVET 40 LLDILICLYD 50 ECNNSPLRRE 60 KNILEYLEWA 70 KPFTSKVKQM 80 RLHREDFEIL 90 KVIGRGAFGE 100 VAVVKLKNAD 110 KVFAMKILNK 120 WEMLKRAETA 130 CFREERDVLV 140 NGDNKWITTL 150 HYAFQDDNNL 160 YLVMDYYVGG 170 DLLTLLSKFE 180 DRLPEDMARF 190 YLAEMVIAID 200 SVHQLHYVHR 210 DIKPDNILMD 220 MNGHIRLADF 230 GSCLKLMEDG 240 TVQSSVAVGT 250 PDYISPEILQ 260 AMEDGKGRYG 270 PECDWWSLGV 280 CMYEMLYGET 290 PFYAESLVET 300 YGKIMNHKER 310 FQFPAQVTDV 320 SENAKDLIRR 330 LICSREHRLG 340 QNGIEDFKKH 350 PFFSGIDWDN 360 IRNCEAPYIP 370 EVSSPTDTSN 380 FDVDDDCLKN 390 SETMPPPTHT 400 AFSGHHLPFV 410 GFTYTSSCVL 420 SDRSCLRVTA 430 GPTSLDLDVN 440 VQRTLDNNLA 450 TEAYERRIKR 460 LEQEKLELSR 470 KLQESTQTVQ 480 ALQYSTVDGP 490 LTASKDLEIK 500 NLKEEIEKLR 510 KQVTESSHLE 520 QQLEEANAVR 530 QELDDAFRQI 540 KAYEKQIKTL 550 QQEREDLNKE 560 LVQASERLKN 570 QSKELKDAHC 580 QRKLAMQEFM 590 EINERLTELH 600 TQKQKLARHV 610 RDKEEEVDLV 620 MQKVESLRQE 630 LRRTERAKKE 640 LEVHTEALAA 650 EASKDRKLRE 660 QSEHYSKQLE 670 NELEGLKQKQ 680 ISYSPGVCSI 690 EHQQEITKLK 700 TDLEKKSIFY 710 EEELSKREGI 720 HANEIKNLKK 730 ELHDSEGQQL 740 ALNKEIMILK 750 DKLEKTRRES 760 QSEREEFESE 770 FKQQYEREKV 780 LLTEENKKLT 790 SELDKLTTLY 800 ENLSIHNQQL 810 EEEVKDLADK 820 KESVAHWEAQ 830 ITEIIQWVSD 840 EKDARGYLQA 850 LASKMTEELE 860 ALRNSSLGTR 870 ATDMPWKMRR 880 FAKLDMSARL 890 ELQSALDAEI 900 RAKQAIQEEL 910 NKVKASNIIT 920 ECKLKDSEKK 930 NLELLSEIEQ 940 LIKDTEELRS 950 EKGIEHQDSQ 960 HSFLAFLNTP 970 TDALDQFERS 980 PSCTPASKGR 990 RTVDSTPLSV 1000 HTPTLRKKGC 1010 PGSTGFPPKR 1020 KTHQFFVKSF 1030 TTPTKCHQCT 1040 SLMVGLIRQG 1050 CSCEVCGFSC 1060 HITCVNKAPT 1070 TCPVPPEQTK 1080 GPLGIDPQKG 1090 IGTAYEGHVR 1100 IPKPAGVKKG 1110 WQRALAIVCD 1120 FKLFLYDIAE 1130 GKASQPSVVI 1140 SQVIDMRDEE 1150 FSVSSVLASD 1160 VIHASRKDIP 1170 CIFRVTASQL 1180 SASNNKCSIL 1190 MLADTENEKN 1200 KWVGVLSELH 1210 KILKKNKFRD 1220 RSVYVPKEAY 1230 DSTLPLIKTT 1240 QAAAIIDHER 1250 IALGNEEGLF 1260 VVHVTKDEII 1270 RVGDNKKIHQ 1280 IELIPNDQLV 1290 AVISGRNRHV 1300 RLFPMSALDG 1310 RETDFYKLSE 1320 TKGCQTVTSG 1330 KVRHGALTCL 1340 CVAMKRQVLC 1350 YELFQSKTRH 1360 RKFKEIQVPY 1370 NVQWMAIFSE 1380 QLCVGFQSGF 1390 LRYPLNGEGN 1400 PYSMLHSNDH 1410 TLSFIAHQPM 1420 DAICAVEISS 1430 KEYLLCFNSI 1440 GIYTDCQGRR 1450 SRQQELMWPA 1460 NPSSCCYNAP 1470 YLSVYSENAV 1480 DIFDVNSMEW 1490 IQTLPLKKVR 1500 PLNNEGSLNL 1510 LGLETIRLIY 1520 FKNKMAEGDE 1530 LVVPETSDNS 1540 RKQMVRNINN 1550 KRRYSFRVPE 1560 EERMQQRREM 1570 LRDPEMRNKL 1580 ISNPTNFNHI 1590 AHMGPGDGIQ 1600 ILKDLPMNPR 1610 PQESRTVFSG 1620 SVSIPSITKS 1630 RPEPGRSMSA 1640 SSGLSARSSA 1650 QNGSALKREF 1660 SGGSYSAKRQ 1670 PMPSPSEGSL 1680 SSGGMDQGSD 1690 APARDFDGED 1700 SDSPRHSTAS 1710 NSSNLSSPPS 1720 PASPRKTKSL 1730 SLESTDRGSW DP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0030027	lamellipodium
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0016477	cell migration
Biological Process	GO:0006468	protein phosphorylation

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.