Search Results

Overview

Uniprot IDQ5VT52
Protein NameRegulation of nuclear pre-mRNA domain-containing protein 2
Gene NameRPRD2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1010 TTSTIEFKNMLKNAS
1014 IEFKNMLKNASRKPS
150 EALSTTFKTQKQLKE
177 SQTSTNPKAALKSKI
183 PKAALKSKIVAEFRS
671 TSPSLEMKIHNFLKG
862 KSILKSSKLSDTTEY

Function

No function data available.

Protein Sequence

10 MAAGGGGGSS 20 KASSSSASSA 30 GALESSLDRK 40 FQSVTNTMES 50 IQGLSSWCIE 60 NKKHHSTIVY 70 HWMKWLRRSA 80 YPHRLNLFYL 90 ANDVIQNCKR 100 KNAIIFRESF 110 ADVLPEAAAL 120 VKDPSVSKSV 130 ERIFKIWEDR 140 NVYPEEMIVA 150 LREALSTTFK 160 TQKQLKENLN 170 KQPNKQWKKS 180 QTSTNPKAAL 190 KSKIVAEFRS 200 QALIEELLLY 210 KRSEDQIELK 220 EKQLSTMRVD 230 VCSTETLKCL 240 KDKTGGKKFS 250 KEFEEASSKL 260 EEFVNGLDKQ 270 VKNGPSLTEA 280 LENAGIFYEA 290 QYKEVKVVAN 300 AYKTFANRVN 310 NLKKKLDQLK 320 STLPDPEESP 330 VPSPSMDAPS 340 PTGSESPFQG 350 MGGEESQSPT 360 MESEKSATPE 370 PVTDNRDVED 380 MELSDVEDDG 390 SKIIVEDRKE 400 KPAEKSAVST 410 SVPTKPTENI 420 SKASSCTPVP 430 VTMTATPPLP 440 KPVNTSLSPS 450 PALALPNLAN 460 VDLAKISSIL 470 SSLTSVMKNT 480 GVSPASRPSP 490 GTPTSPSNLT 500 SGLKTPAPAT 510 TTSHNPLANI 520 LSKVEITPES 530 ILSALSKTQT 540 QSAPALQGLS 550 SLLQSVTGNP 560 VPASEAASQS 570 TSASPANTTV 580 STIKGRNLPS 590 SAQPFIPKSF 600 NYSPNSSTSE 610 VSSTSASKAS 620 IGQSPGLPST 630 TFKLPSNSLG 640 FTATHNTSPA 650 APPTEVTICQ 660 SSEVSKPKLE 670 SESTSPSLEM 680 KIHNFLKGNP 690 GFSGLNLNIP 700 ILSSLGSSAP 710 SESHPSDFQR 720 GPTSTSIDNI 730 DGTPVRDERS 740 GTPTQDEMMD 750 KPTSSSVDTM 760 SLLSKIISPG 770 SSTPSSTRSP 780 PPGRDESYPR 790 ELSNSVSTYR 800 PFGLGSESPY 810 KQPSDGMERP 820 SSLMDSSQEK 830 FYPDTSFQED 840 EDYRDFEYSG 850 PPPSAMMNLE 860 KKPAKSILKS 870 SKLSDTTEYQ 880 PILSSYSHRA 890 QEFGVKSAFP 900 PSVRALLDSS 910 ENCDRLSSSP 920 GLFGAFSVRG 930 NEPGSDRSPS 940 PSKNDSFFTP 950 DSNHNSLSQS 960 TTGHLSLPQK 970 QYPDSPHPVP 980 HRSLFSPQNT 990 LAAPTGHPPT 1000 SGVEKVLAST 1010 ISTTSTIEFK 1020 NMLKNASRKP 1030 SDDKHFGQAP 1040 SKGTPSDGVS 1050 LSNLTQPSLT 1060 ATDQQQQEEH 1070 YRIETRVSSS 1080 CLDLPDSTEE 1090 KGAPIETLGY 1100 HSASNRRMSG 1110 EPIQTVESIR 1120 VPGKGNRGHG 1130 REASRVGWFD 1140 LSTSGSSFDN 1150 GPSSASELAS 1160 LGGGGSGGLT 1170 GFKTAPYKER 1180 APQFQESVGS 1190 FRSNSFNSTF 1200 EHHLPPSPLE 1210 HGTPFQREPV 1220 GPSSAPPVPP 1230 KDHGGIFSRD 1240 APTHLPSVDL 1250 SNPFTKEAAL 1260 AHAAPPPPPG 1270 EHSGIPFPTP 1280 PPPPPPGEHS 1290 SSGGSGVPFS 1300 TPPPPPPPVD 1310 HSGVVPFPAP 1320 PLAEHGVAGA 1330 VAVFPKDHSS 1340 LLQGTLAEHF 1350 GVLPGPRDHG 1360 GPTQRDLNGP 1370 GLSRVRESLT 1380 LPSHSLEHLG 1390 PPHGGGGGGG 1400 SNSSSGPPLG 1410 PSHRDTISRS 1420 GIILRSPRPD 1430 FRPREPFLSR 1440 DPFHSLKRPR 1450 PPFARGPPFF 1460 APKRPFFPPR Y

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0097550 transcription preinitiation complex
Molecular Function GO:0099122 RNA polymerase II C-terminal domain binding
Molecular Function GO:0000993 RNA polymerase II complex binding
Biological Process GO:0031124 mRNA 3'-end processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.