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Overview

Uniprot ID	Q5VTE0
Protein Name	Putative elongation factor 1-alpha-like 3
Gene Name	EEF1A1P5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
172	KRYEEIVKEVSTYIK
179	KEVSTYIKKIGYNPD
219	KGWKVTRKDGNASGT
244	PPTRPTDKPLRLPLQ
255	LPLQDVYKIGGIGTV
386	IDRRSGKKLEDGPKF
392	KKLEDGPKFLKSGDA
41	IDKRTIEKFEKEAAE
439	TVAVGVIKAVDKKAA
44	RTIEKFEKEAAEMGK
450	KKAAGAGKVTKSAQK
453	AGAGKVTKSAQKAQK
457	KVTKSAQKAQKAK**
5	***MGKEKTHINIVV

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Protein Sequence

10 MGKEKTHINI 20 VVIGHVDSGK 30 STTTGHLIYK 40 CGGIDKRTIE 50 KFEKEAAEMG 60 KGSFKYAWVL 70 DKLKAERERG 80 ITIDISLWKF 90 ETSKYYVTII 100 DAPGHRDFIK 110 NMITGTSQAD 120 CAVLIVAAGV 130 GEFEAGISKN 140 GQTREHALLA 150 YTLGVKQLIV 160 GVNKMDSTEP 170 PYSQKRYEEI 180 VKEVSTYIKK 190 IGYNPDTVAF 200 VPISGWNGDN 210 MLEPSANMPW 220 FKGWKVTRKD 230 GNASGTTLLE 240 ALDCILPPTR 250 PTDKPLRLPL 260 QDVYKIGGIG 270 TVPVGRVETG 280 VLKPGMVVTF 290 APVNVTTEVK 300 SVEMHHEALS 310 EALPGDNVGF 320 KVKNVSVKDV 330 RRGNVAGDSK 340 NDPPMEAAGF 350 TAQVIILNHP 360 GQISAGYAPV 370 LDCHMAHIAC 380 KFAELKEKID 390 RRSGKKLEDG 400 PKFLKSGDAA 410 IVDMVPGKPM 420 CVESFSDYPP 430 LGRFAVRDMR 440 QTVAVGVIKA 450 VDKKAAGAGK 460 VTKSAQKAQK AK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0006412	translation
Biological Process	GO:0006414	translational elongation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.