Search Results

Overview

Uniprot IDQ5VTL8
Protein NamePre-mRNA-splicing factor 38B
Gene NamePRPF38B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 PWEKGSRKTAGQTGM
42 TKPAVSGKQGNVLPL
484 GRTDSVEKSKKREHS

Function

May be required for pre-mRNA splicing

Protein Sequence

10 MANNSPALTG 20 NSQPQHQAAA 30 AAAQQQQQCG 40 GGGATKPAVS 50 GKQGNVLPLW 60 GNEKTMNLNP 70 MILTNILSSP 80 YFKVQLYELK 90 TYHEVVDEIY 100 FKVTHVEPWE 110 KGSRKTAGQT 120 GMCGGVRGVG 130 TGGIVSTAFC 140 LLYKLFTLKL 150 TRKQVMGLIT 160 HTDSPYIRAL 170 GFMYIRYTQP 180 PTDLWDWFES 190 FLDDEEDLDV 200 KAGGGCVMTI 210 GEMLRSFLTK 220 LEWFSTLFPR 230 IPVPVQKNID 240 QQIKTRPRKI 250 KKDGKEGAEE 260 IDRHVERRRS 270 RSPRRSLSPR 280 RSPRRSRSRS 290 HHREGHGSSS 300 FDRELEREKE 310 RQRLEREAKE 320 REKERRRSRS 330 IDRGLERRRS 340 RSRERHRSRS 350 RSRDRKGDRR 360 DRDREREKEN 370 ERGRRRDRDY 380 DKERGNEREK 390 ERERSRERSK 400 EQRSRGEVEE 410 KKHKEDKDDR 420 RHRDDKRDSK 430 KEKKHSRSRS 440 RERKHRSRSR 450 SRNAGKRSRS 460 RSKEKSSKHK 470 NESKEKSNKR 480 SRSGSQGRTD 490 SVEKSKKREH 500 SPSKEKSRKR 510 SRSKERSHKR 520 DHSDSKDQSD 530 KHDRRRSQSI 540 EQESQEKQHK NKDETV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071011 precatalytic spliceosome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.