Search Results

Overview

Uniprot ID	Q5VV41
Protein Name	Rho guanine nucleotide exchange factor 16
Gene Name	ARHGEF16
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
100	LAVASKAKTPARHQS
98	KSLAVASKAKTPARH

Function

Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6

Protein Sequence

10 MAQRHSDSSL 20 EEKLLGHRFH 30 SELRLDAGGN 40 PASGLPMVRG 50 SPRVRDDAAF 60 QPQVPAPPQP 70 RPPGHEEPWP 80 IVLSTESPAA 90 LKLGTQQLIP 100 KSLAVASKAK 110 TPARHQSFGA 120 AVLSREAARR 130 DPKLLPAPSF 140 SLDDMDVDKD 150 PGGMLRRNLR 160 NQSYRAAMKG 170 LGKPGGQGDA 180 IQLSPKLQAL 190 AEEPSQPHTR 200 SPAKNKKTLG 210 RKRGHKGSFK 220 DDPQLYQEIQ 230 ERGLNTSQES 240 DDDILDESSS 250 PEGTQKVDAT 260 IVVKSYRPAQ 270 VTWSQLPEVV 280 ELGILDQLST 290 EERKRQEAMF 300 EILTSEFSYQ 310 HSLSILVEEF 320 LQSKELRATV 330 TQMEHHHLFS 340 NILDVLGASQ 350 RFFEDLEQRH 360 KAQVLVEDIS 370 DILEEHAEKH 380 FHPYIAYCSN 390 EVYQQRTLQK 400 LISSNAAFRE 410 ALREIERRPA 420 CGGLPMLSFL 430 ILPMQRVTRL 440 PLLMDTLCLK 450 TQGHSERYKA 460 ASRALKAISK 470 LVRQCNEGAH 480 RMERMEQMYT 490 LHTQLDFSKV 500 KSLPLISASR 510 WLLKRGELFL 520 VEETGLFRKI 530 ASRPTCYLFL 540 FNDVLVVTKK 550 KSEESYMVQD 560 YAQMNHIQVE 570 KIEPSELPLP 580 GGGNRSSSVP 590 HPFQVTLLRN 600 SEGRQEQLLL 610 SSDSASDRAR 620 WIVALTHSER 630 QWQGLSSKGD 640 LPQVEITKAF 650 FAKQADEVTL 660 QQADVVLVLQ 670 QEDGWLYGER 680 LRDGETGWFP 690 EDFARFITSR 700 VAVEGNVRRM ERLRVETDV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Molecular Function	GO:0030165	PDZ domain binding
Molecular Function	GO:0030971	receptor tyrosine kinase binding
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0090630	activation of GTPase activity
Biological Process	GO:0060326	cell chemotaxis
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane
Biological Process	GO:0032956	regulation of actin cytoskeleton organization
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.