Overview
| Uniprot ID | Q5VVJ2 |
|---|
| Protein Name | Deubiquitinase MYSM1 |
|---|
| Gene Name | MYSM1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 315 |
SIELNDQKFNELIKN |
Function
Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232)
Protein Sequence
10
MAAEEADVDI
20
EGDVVAAAGA
30
QPGSGENTAS
40
VLQKDHYLDS
50
SWRTENGLIP
60
WTLDNTISEE
70
NRAVIEKMLL
80
EEEYYLSKKS
90
QPEKVWLDQK
100
EDDKKYMKSL
110
QKTAKIMVHS
120
PTKPASYSVK
130
WTIEEKELFE
140
QGLAKFGRRW
150
TKISKLIGSR
160
TVLQVKSYAR
170
QYFKNKVKCG
180
LDKETPNQKT
190
GHNLQVKNED
200
KGTKAWTPSC
210
LRGRADPNLN
220
AVKIEKLSDD
230
EEVDITDEVD
240
ELSSQTPQKN
250
SSSDLLLDFP
260
NSKMHETNQG
270
EFITSDSQEA
280
LFSKSSRGCL
290
QNEKQDETLS
300
SSEITLWTEK
310
QSNGDKKSIE
320
LNDQKFNELI
330
KNCNKHDGRG
340
IIVDARQLPS
350
PEPCEIQKNL
360
NDNEMLFHSC
370
QMVEESHEEE
380
ELKPPEQEIE
390
IDRNIIQEEE
400
KQAIPEFFEG
410
RQAKTPERYL
420
KIRNYILDQW
430
EICKPKYLNK
440
TSVRPGLKNC
450
GDVNCIGRIH
460
TYLELIGAIN
470
FGCEQAVYNR
480
PQTVDKVRIR
490
DRKDAVEAYQ
500
LAQRLQSMRT
510
RRRRVRDPWG
520
NWCDAKDLEG
530
QTFEHLSAEE
540
LAKRREEEKG
550
RPVKSLKVPR
560
PTKSSFDPFQ
570
LIPCNFFSEE
580
KQEPFQVKVA
590
SEALLIMDLH
600
AHVSMAEVIG
610
LLGGRYSEVD
620
KVVEVCAAEP
630
CNSLSTGLQC
640
EMDPVSQTQA
650
SETLAVRGFS
660
VIGWYHSHPA
670
FDPNPSLRDI
680
DTQAKYQSYF
690
SRGGAKFIGM
700
IVSPYNRNNP
710
LPYSQITCLV
720
ISEEISPDGS
730
YRLPYKFEVQ
740
QMLEEPQWGL
750
VFEKTRWIIE
760
KYRLSHSSVP
770
MDKIFRRDSD
780
LTCLQKLLEC
790
MRKTLSKVTN
800
CFMAEEFLTE
810
IENLFLSNYK
820
SNQENGVTEE
NCTKELLM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0140950 |
histone H2A deubiquitinase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0140492 |
metal-dependent deubiquitinase activity |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0002376 |
immune system process |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:1903706 |
regulation of hemopoiesis |
Reference
PMID: N/A