Search Results
Overview
| Uniprot ID | Q5VW32 |
|---|---|
| Protein Name | BRO1 domain-containing protein BROX |
| Gene Name | BROX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | NITEDEAKEVHRSLK |
| 302 | KGPGPTVKPSGHLFF |
Function
Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane
Protein Sequence
10
MTHWFHRNPL
20
KATAPVSFNY
30
YGVVTGPSAS
40
KICNDLRSSR
50
ARLLELFTDL
60
SCNPEMMKNA
70
ADSYFSLLQG
80
FINSLDESTQ
90
ESKLRYIQNF
100
KWTDTLQGQV
110
PSAQQDAVFE
120
LISMGFNVAL
130
WYTKYASRLA
140
GKENITEDEA
150
KEVHRSLKIA
160
AGIFKHLKES
170
HLPKLITPAE
180
KGRDLESRLI
190
EAYVIQCQAE
200
AQEVTIARAI
210
ELKHAPGLIA
220
ALAYETANFY
230
QKADHTLSSL
240
EPAYSAKWRK
250
YLHLKMCFYT
260
AYAYCYHGET
270
LLASDKCGEA
280
IRSLQEAEKL
290
YAKAEALCKE
300
YGETKGPGPT
310
VKPSGHLFFR
320
KLGNLVKNTL
330
EKCQRENGFI
340
YFQKIPTEAP
350
QLELKANYGL
360
VEPIPFEFPP
370
TSVQWTPETL
380
AAFDLTKRPK
390
DDSTKPKPEE
400
EVKPVKEPDI
410
KPQKDTGCYI
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0031965 | nuclear membrane |
| Biological Process | GO:0007084 | mitotic nuclear membrane reassembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.