Search Results

Overview

Uniprot IDQ5VWN6
Protein NameProtein TASOR 2
Gene NameTASOR2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
115 LTECIKNKQLAIIKC
469 KQRVNIVKGNENPRN
490 VKGETASKLQSEISR

Function

Core component of the HUSH2 complex, a multiprotein complex that mediates epigenetic repression of interferon-stimulated genes (PubMed:39013473, PubMed:39489739). TASOR2 is recruited to interferon-stimulated genes by IRF2, leading to transcriptional silencing by the HUSH2 complex via a H3K9me3-independent mechanism (PubMed:39013473). Within the HUSH2 complex, TASOR2 acts as the central scaffold, which recruits MPHOSPH8 and PPHLN1 (PubMed:39013473)

Protein Sequence

10 MAPPAHKSIL 20 ERSENVLMSP 30 WKGKLIVQDR 40 MLCDIALWST 50 YGAMIPTQLP 60 QELDFKYVMK 70 VSSLKKRLPE 80 AAFRKQNYLE 90 EKVCFQDLCF 100 NLYEVELSNR 110 QGENIDKLTE 120 CIKNKQLAII 130 KCLEDRGFFI 140 LLTSSALLSE 150 PDFGGKQMGL 160 HGLHLFRSPL 170 STGVKDLKVE 180 DDISMKVIPI 190 LSTLNCALLE 200 TKKSLPEERI 210 HPNTLVKRHF 220 QELYKADRSP 230 SLSVAPQDRM 240 KDPTFLGKLP 250 SGFDLIPPAE 260 KCPSESLTQL 270 NSYFSDPSAY 280 ILEVSTALDL 290 LAEHPQSPCV 300 SDGICDAGFS 310 LVMTPDPEFL 320 VSEAEVRKET 330 ETKKDSEEML 340 KAKKRVFPLS 350 PASNLRVQPK 360 RKASMPHMVQ 370 SKKVNLCRPF 380 PKRTASRADN 390 SSDSPTTLKL 400 VKGQFPQKRK 410 RGAEVLTAQF 420 VQKTKLDRKN 430 QEAPISKDVP 440 VPTNAKRARK 450 QEKSPVKTVP 460 RAKPPVKKSP 470 QKQRVNIVKG 480 NENPRNRKQL 490 QPVKGETASK 500 LQSEISRGCQ 510 EDGISINSVQ 520 PENTTAAHND 530 LPENSIVNYD 540 SQALNMLADL 550 ALSSATSSTP 560 VSEARNLHCS 570 SELPQNDVLL 580 SKENSLRGTS 590 DHEYHRGVKT 600 QKGELLPNPS 610 SDRKSNSGSD 620 LTVSQDEESL 630 VPCSQAPAKA 640 QSALTEEMLE 650 SSDASQSSSV 660 SVEHSYALLL 670 TEHSKKHLQE 680 REILSPLFPR 690 NGTKSPEAAT 700 PVGKVMPFRH 710 QPGLLLQQKP 720 PDDPVVKPKD 730 RPPSARVKKS 740 SCSRIVLSCD 750 DSVKITFKCE 760 TEYAFSLDSK 770 YTNNPLEKTV 780 VRALHGPWNT 790 DLPDNVEEVK 800 LLLHMWVALF 810 YSNQNKIIRS 820 SRKVVEHSNP 830 AKYVSINSTL 840 ESCELREIEE 850 SLGLEKCSAD 860 SLLETNEISR 870 AHAAEVSFRD 880 PNCLLPFIKT 890 PLTQGLELCV 900 QNEQKKTFAR 910 ECDPDTQEDQ 920 NFICSYNNEV 930 TGEEAKQESL 940 ETSNLVLSGI 950 GSTQTNGPSV 960 PSEEEIVQPL 970 DSTRVASYSG 980 TVTQATFTRT 990 YDGPGSQPVI 1000 CQSSVYGTLE 1010 NKVDILDAAV 1020 QTKTGTLQDL 1030 IQHGSPINNE 1040 CHPSLERKDD 1050 NMGCAVINPE 1060 PITLTFEKNA 1070 HVPIQTEGVN 1080 TADERTTFKK 1090 ELIKQVSPAA 1100 SLRHPVSTSE 1110 NARTQGLRDI 1120 PSLVVAGQKG 1130 TKYLCASSVG 1140 GETLDKAVCS 1150 LQKETPLPVS 1160 LPSDKTMVME 1170 ALSLAKSSSH 1180 LSPSEEVRCT 1190 QDFLSQTQSL 1200 LGLSSEGLLE 1210 LTQVEVDSSS 1220 ASTTLGRQCS 1230 LNCISSGCHT 1240 SGDSLELRKN 1250 HKNGPNTENM 1260 NLEAFDSVFI 1270 KQTSLSVSRE 1280 VSLELSEEDS 1290 DIDLALTISP 1300 PTSPREEMPA 1310 GEIEQFEEAP 1320 FSNLELQDVA 1330 EEIGEPEEVA 1340 LTESREVSSA 1350 DNVSVYPSVS 1360 EEPVENKERK 1370 GDNLQPVTLI 1380 LSKENCTLEI 1390 AEEINVTSDF 1400 PFDSVIEEVS 1410 PASSPEPPVP 1420 VKETRPYQAV 1430 TPCILKLHGT 1440 QCEKSNQISQ 1450 CESEDLGITE 1460 KENVFVGPTH 1470 PVGQDNFTQV 1480 QQMQVSAEMP 1490 LILTDHPGRT 1500 GRPTLPGKVT 1510 EEIVSSEHDE 1520 GLSFSGKVQC 1530 YGRELNQPAS 1540 AAKCTGDFSP 1550 SPEKLVKSGN 1560 PLQPVSIENR 1570 NLDLKHLVLE 1580 SSEPPFGPRN 1590 VIENKSLSDT 1600 LVSTTAPSGI 1610 VNVSVKQQTS 1620 PKSSQNHLFP 1630 GDLKTDEGIY 1640 LQVKSLTAAS 1650 VDGAYSTQGC 1660 MCSVVPTLCS 1670 SSDNATLTHY 1680 VRPINAEPVF 1690 QAQEIPAGRM 1700 ASLLKNGEPE 1710 AELHKETTGP 1720 GTAGPQSNTT 1730 SSLKGERKAI 1740 HTLQDVSTCE 1750 TKELLNVGVS 1760 SLCAGPYQNT 1770 ADTKENLSKE 1780 PLASFVSESF 1790 DTSVCGIATE 1800 HVEIENSGEG 1810 LRAEAGSETL 1820 GRDGEVGVNS 1830 DMHYELSGDS 1840 DLDLLGDCRN 1850 PRLDLEDSYT 1860 LRGSYTRKKD 1870 VPTDGYESSL 1880 NFHNNNQEDW 1890 GCSSWVPGME 1900 TSLPPGHWTA 1910 AVKKEEKCVP 1920 PYVQIRDLHG 1930 ILRTYANFSI 1940 TKELKDTMRT 1950 SHGLRRHPSF 1960 SANCGLPSSW 1970 TSTWQVADDL 1980 TQNTLDLEYL 1990 RFAHKLKQTI 2000 KNGDSQHSAS 2010 SANVFPKESP 2020 TQISIGAFPS 2030 TKISEAPFLH 2040 PAPRSRSPLL 2050 VTVVESDPRP 2060 QGQPRRGYTA 2070 SSLDSSSSWR 2080 ERCSHNRDLR 2090 NSQRNHTVSF 2100 HLNKLKYNST 2110 VKESRNDISL 2120 ILNEYAEFNK 2130 VMKNSNQFIF 2140 QDKELNDVSG 2150 EATAQEMYLP 2160 FPGRSASYED 2170 IIIDVCTNLH 2180 VKLRSVVKEA 2190 CKSTFLFYLV 2200 ETEDKSFFVR 2210 TKNLLRKGGH 2220 TEIEPQHFCQ 2230 AFHRENDTLI 2240 IIIRNEDISS 2250 HLHQIPSLLK 2260 LKHFPSVIFA 2270 GVDSPGDVLD 2280 HTYQELFRAG 2290 GFVISDDKIL 2300 EAVTLVQLKE 2310 IIKILEKLNG 2320 NGRWKWLLHY 2330 RENKKLKEDE 2340 RVDSTAHKKN 2350 IMLKSFQSAN 2360 IIELLHYHQC 2370 DSRSSTKAEI 2380 LKCLLNLQIQ 2390 HIDARFAVLL 2400 TDKPTIPREV 2410 FENSGILVTD 2420 VNNFIENIEK 2430 IAAPFRSSYW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0140286 HUSH2 complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0032480 negative regulation of type I interferon production

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.