Search Results

Overview

Uniprot IDQ5VWQ0
Protein NameLysine-specific demethylase 9
Gene NameRSBN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
313 KESFRYLKDEQLCRL
559 RRSMNEIKNLQYLPR

Function

Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2) and trimethylated 'Lys-20' of histone H4 (H4K20me3) into monomethyl H4K20 (H4K20me1) thereby modulating chromosome architecture. May play a critical role in regulating H4K20 methylation during spermatogenesis

Protein Sequence

10 MFISGRRTAD 20 KWRAEERLQC 30 PAGSARAALA 40 RCADGGAVGP 50 FKCVFVGEMA 60 AQVGAVRVVR 70 AVAAQEEPDK 80 EGKEKPHAGV 90 SPRGVKRQRR 100 SSSGGSQEKR 110 GRPSQEPPLA 120 PPHRRRRSRQ 130 HPGPLPPTNA 140 APTVPGPVEP 150 LLLPPPPPPS 160 LAPAGPAVAA 170 PLPAPSTSAL 180 FTFSPLTVSA 190 AGPKHKGHKE 200 RHKHHHHRGP 210 DGDPSSCGTD 220 LKHKDKQENG 230 ERTGGVPLIK 240 APKRETPDEN 250 GKTQRADDFV 260 LKKIKKKKKK 270 KHREDMRGRR 280 LKMYNKEVQT 290 VCAGLTRISK 300 EILTQGQINS 310 TSGLNKESFR 320 YLKDEQLCRL 330 NLGMQEYRVP 340 QGVQTPFMTH 350 QEHSIRRNFL 360 KTGTKFSNFI 370 HEEHQSNGGA 380 LVLHAYMDEL 390 SFLSPMEMER 400 FSEEFLALTF 410 SENEKNAAYY 420 ALAIVHGAAA 430 YLPDFLDYFA 440 FNFPNTPVKM 450 EILGKKDIET 460 TTISNFHTQV 470 NRTYCCGTYR 480 AGPMRQISLV 490 GAVDEEVGDY 500 FPEFLDMLEE 510 SPFLKMTLPW 520 GTLSSLRLQC 530 RSQSDDGPIM 540 WVRPGEQMIP 550 TADMPKSPFK 560 RRRSMNEIKN 570 LQYLPRTSEP 580 REVLFEDRTR 590 AHADHVGQGF 600 DWQSTAAVGV 610 LKAVQFGEWS 620 DQPRITKDVI 630 CFHAEDFTDV 640 VQRLQLDLHE 650 PPVSQCVQWV 660 DEAKLNQMRR 670 EGIRYARIQL 680 CDNDIYFIPR 690 NVIHQFKTVS 700 AVCSLAWHIR 710 LKQYHPVVEA 720 TQNTESNSNM 730 DCGLTGKREL 740 EVDSQCVRIK 750 TESEEACTEI 760 QLLTTASSSF 770 PPASELNLQQ 780 DQKTQPIPVL 790 KVESRLDSDQ 800 QHNLQEHSTT SV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0035575 histone H4K20 demethylase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007283 spermatogenesis

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.