Search Results

Overview

Uniprot ID	Q5VWZ2
Protein Name	Lysophospholipase-like protein 1
Gene Name	LYPLAL1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
235	KLPGEMEKQK*****
70	PRSYTPMKGGISNVW

Function

Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1 (PubMed:22052940, PubMed:22399288, PubMed:37802025). Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity (PubMed:37802025). Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (PubMed:22052940)

Protein Sequence

10 MAAASGSVLQ 20 RCIVSPAGRH 30 SASLIFLHGS 40 GDSGQGLRMW 50 IKQVLNQDLT 60 FQHIKIIYPT 70 APPRSYTPMK 80 GGISNVWFDR 90 FKITNDCPEH 100 LESIDVMCQV 110 LTDLIDEEVK 120 SGIKKNRILI 130 GGFSMGGCMA 140 IHLAYRNHQD 150 VAGVFALSSF 160 LNKASAVYQA 170 LQKSNGVLPE 180 LFQCHGTADE 190 LVLHSWAEET 200 NSMLKSLGVT 210 TKFHSFPNVY 220 HELSKTELDI 230 LKLWILTKLP GEMEKQK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds
Molecular Function	GO:0008474	palmitoyl-(protein) hydrolase activity
Molecular Function	GO:0004622	phosphatidylcholine lysophospholipase A1 activity
Biological Process	GO:0160049	negative regulation of cGAS/STING signaling pathway
Biological Process	GO:0042997	negative regulation of Golgi to plasma membrane protein transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.