Overview
| Uniprot ID | Q5VY09 |
|---|
| Protein Name | Immediate early response gene 5 protein |
|---|
| Gene Name | IER5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 4 |
****MEFKLEAHRIV |
Function
Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193)
Protein Sequence
10
MEFKLEAHRI
20
VSISLGKIYN
30
SRVQRGGIKL
40
HKNLLVSLVL
50
RSARQVYLSD
60
PCPGLYLAGP
70
AGTPAPPPQQ
80
QPGEPAAGPP
90
AGWGEPPPPA
100
ARASWPETEP
110
QPERSSVSDA
120
PRVGDEVPVA
130
TVTGVGDVFQ
140
GGEADATEAA
150
WSRVEGPRQA
160
AAREAEGTAG
170
GWGVFPEVSR
180
AARRPCGCPL
190
GGEDPPGTPA
200
ATPRAACCCA
210
PQPAEDEPPA
220
PPAVCPRKRC
230
AAGVGGGPAG
240
CPAPGSTPLK
250
KPRRNLEQPP
260
SGGEDDDAEE
270
METGNVANLI
280
SIFGSSFSGL
290
LRKSPGGGRE
300
EEEGEESGPE
310
AAEPGQICCD
320
KPVLRDMNPW
STAIVAF
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:1900036 |
positive regulation of cellular response to heat |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0034605 |
cellular response to heat |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0042127 |
regulation of cell population proliferation |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.